Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2021339..2021951 Replicon chromosome
Accession NZ_CP076589
Organism Erwinia amylovora isolate CP201324

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag KQH38_RS09265 Protein ID WP_012906750.1
Coordinates 2021339..2021518 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID D4I356
Locus tag KQH38_RS09270 Protein ID WP_004157632.1
Coordinates 2021541..2021951 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH38_RS09245 (KQH38_09235) 2016897..2017847 + 951 WP_004157624.1 DUF1471 family protein YdgH -
KQH38_RS09250 (KQH38_09240) 2018055..2019446 + 1392 WP_004157625.1 amino acid permease -
KQH38_RS09255 (KQH38_09245) 2019450..2019914 - 465 WP_004157626.1 hypothetical protein -
KQH38_RS09260 (KQH38_09250) 2020091..2020819 + 729 WP_004157629.1 two-component system response regulator RstA -
KQH38_RS09265 (KQH38_09255) 2021339..2021518 + 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
KQH38_RS09270 (KQH38_09260) 2021541..2021951 + 411 WP_004157632.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KQH38_RS09275 (KQH38_09265) 2022007..2023008 + 1002 WP_004157633.1 acyltransferase -
KQH38_RS09280 (KQH38_09270) 2023879..2024091 - 213 WP_004157635.1 hypothetical protein -
KQH38_RS09285 (KQH38_09275) 2024349..2024522 - 174 WP_004157636.1 hypothetical protein -
KQH38_RS09290 (KQH38_09280) 2024617..2024790 - 174 WP_013036045.1 hypothetical protein -
KQH38_RS09295 (KQH38_09285) 2024801..2025073 - 273 WP_004157637.1 hypothetical protein -
KQH38_RS09300 (KQH38_09290) 2025703..2026293 + 591 WP_223386180.1 DapH/DapD/GlmU-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2021339..2031416 10077


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T205967 WP_012906750.1 NZ_CP076589:2021339-2021518 [Erwinia amylovora]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T205967 NZ_CP101941:c14266-13916 [Salmonella enterica subsp. enterica]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14829.76 Da        Isoelectric Point: 4.3623

>AT205967 WP_004157632.1 NZ_CP076589:2021541-2021951 [Erwinia amylovora]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESAREAIDAHIELLVEDGEAVPEATSVENWLADPDYVGVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Download         Length: 411 bp

>AT205967 NZ_CP101941:c13911-13609 [Salmonella enterica subsp. enterica]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A830ZVY0

References