Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 848166..848832 Replicon chromosome
Accession NZ_CP076589
Organism Erwinia amylovora isolate CP201324

Toxin (Protein)


Gene name cptA Uniprot ID A0A830ZTB8
Locus tag KQH38_RS03785 Protein ID WP_004161808.1
Coordinates 848413..848832 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D4HWC2
Locus tag KQH38_RS03780 Protein ID WP_004155593.1
Coordinates 848166..848432 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH38_RS03760 (KQH38_03765) 844639..845368 + 730 Protein_736 SDR family oxidoreductase -
KQH38_RS03765 (KQH38_03770) 845473..846081 - 609 WP_004155587.1 HD domain-containing protein -
KQH38_RS03770 (KQH38_03775) 846294..846953 + 660 WP_004155588.1 hemolysin III family protein -
KQH38_RS03775 (KQH38_03780) 846954..847940 - 987 WP_004155590.1 tRNA-modifying protein YgfZ -
KQH38_RS03780 (KQH38_03785) 848166..848432 + 267 WP_004155593.1 FAD assembly factor SdhE Antitoxin
KQH38_RS03785 (KQH38_03790) 848413..848832 + 420 WP_004161808.1 protein YgfX Toxin
KQH38_RS03790 (KQH38_03795) 848950..849468 - 519 WP_004155596.1 flavodoxin FldB -
KQH38_RS03795 (KQH38_03800) 849698..850651 - 954 WP_004155597.1 DMT family transporter -
KQH38_RS03800 (KQH38_03805) 851161..852840 - 1680 WP_004155599.1 type III effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16366.46 Da        Isoelectric Point: 11.9444

>T205964 WP_004161808.1 NZ_CP076589:848413-848832 [Erwinia amylovora]
VVLWQCELRPSRLAQRFSLLLHGAVMLALLLPTWPASSGLVRMLLLVLVLLECIRSRRRIGRRQGDIALLEGHELRWRQR
EWCIISRPWLTGQAILLLLQDTHGQRERLWLFADGMEKRNWRQLRLQLLNSKVQGNGWC

Download         Length: 420 bp

>T205964 NZ_CP101940:3986750-3987163 [Salmonella enterica subsp. enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10498.07 Da        Isoelectric Point: 6.4605

>AT205964 WP_004155593.1 NZ_CP076589:848166-848432 [Erwinia amylovora]
MDITNKSRIHWACRRGMRELDISIMPFFQYEFDSLNDSDKRLFVRLLESDDPDLFNWLMNHGEPADVELKRMVALIQQRN
KQRGPVAM

Download         Length: 267 bp

>AT205964 NZ_CP101940:3986503-3986769 [Salmonella enterica subsp. enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A830ZTB8

Antitoxin

Source ID Structure
AlphaFold DB A0A831A3F0

References