Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 77467..78143 Replicon chromosome
Accession NZ_CP076556
Organism Sphingobium xenophagum strain PH3-15

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GTV57_RS00265 Protein ID WP_197421620.1
Coordinates 77467..77865 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GTV57_RS00270 Protein ID WP_066768550.1
Coordinates 77877..78143 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTV57_RS00245 (GTV57_00245) 73254..74333 - 1080 WP_066768563.1 hypothetical protein -
GTV57_RS00250 (GTV57_00250) 74350..74811 - 462 WP_066768561.1 hypothetical protein -
GTV57_RS00255 (GTV57_00255) 75510..75893 - 384 WP_066768557.1 hypothetical protein -
GTV57_RS00260 (GTV57_00260) 75934..77196 - 1263 WP_231736731.1 hypothetical protein -
GTV57_RS00265 (GTV57_00265) 77467..77865 - 399 WP_197421620.1 type II toxin-antitoxin system VapC family toxin Toxin
GTV57_RS00270 (GTV57_00270) 77877..78143 - 267 WP_066768550.1 antitoxin Antitoxin
GTV57_RS00275 (GTV57_00275) 78244..79020 - 777 WP_066768548.1 PRTRC system ThiF family protein -
GTV57_RS00280 (GTV57_00280) 79010..79669 - 660 WP_066768543.1 PRTRC system protein A -
GTV57_RS00285 (GTV57_00285) 79666..80502 - 837 WP_066768541.1 PRTRC system protein B -
GTV57_RS00290 (GTV57_00290) 80511..81434 - 924 WP_231736730.1 hypothetical protein -
GTV57_RS00295 (GTV57_00295) 81681..81887 - 207 WP_066768529.1 PRTRC system protein C -
GTV57_RS00300 (GTV57_00300) 81933..82358 - 426 WP_066768525.1 PRTRC system protein E -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

SpoVT-AbrB domain

(16-62)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14157.43 Da        Isoelectric Point: 4.9058

>T205958 WP_197421620.1 NZ_CP076556:c77865-77467 [Sphingobium xenophagum]
MLDTNIVSDLVRNPQGRVFEKIVKVGSDRLCISVITAAELRYGCAKKGSAKLLAQVEAILAGIEILPFDVPGDAEYGGIR
AELEAAGCPIGPNDLLIAAHAYAVSAILVTANVDEFRRIRGLKIENWLEPQA

Download         Length: 399 bp

>T205958 NZ_CP101940:c2431500-2431216 [Salmonella enterica subsp. enterica]
ATGACTTATGAACTGGAAATCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9791.24 Da        Isoelectric Point: 4.4857

>AT205958 WP_066768550.1 NZ_CP076556:c78143-77877 [Sphingobium xenophagum]
MAQPISTSVVREAKLFRNNRSQAVRIPAEFEFSGSRVLIHKEGDKLIIEPEPRANLVDILKALAPLAPDDDFPEDLDATL
LPLKDVDL

Download         Length: 267 bp

>AT205958 NZ_CP101940:c2431732-2431490 [Salmonella enterica subsp. enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTTTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References