Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 7773..8353 Replicon plasmid p7
Accession NZ_CP076551
Organism Klebsiella pneumoniae strain 19PDR22

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag HF574_RS28400 Protein ID WP_071177730.1
Coordinates 7773..8087 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag HF574_RS28405 Protein ID WP_000093040.1
Coordinates 8075..8353 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF574_RS28375 (HF574_29110) 3717..5681 + 1965 WP_071177727.1 TraM recognition domain-containing protein -
HF574_RS28380 (HF574_29115) 5681..6412 + 732 WP_071177728.1 MobC family replication-relaxation protein -
HF574_RS28385 (HF574_29120) 6419..6949 + 531 WP_071177729.1 hypothetical protein -
HF574_RS28390 (HF574_29125) 6976..7155 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
HF574_RS28395 (HF574_29130) 7181..7609 - 429 WP_001140599.1 hypothetical protein -
HF574_RS28400 (HF574_29135) 7773..8087 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HF574_RS28405 (HF574_29140) 8075..8353 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
HF574_RS30505 8528..8893 - 366 WP_072354022.1 TonB family protein -
HF574_RS28415 (HF574_29150) 8890..9261 - 372 WP_001237044.1 cell envelope integrity protein TolA -
HF574_RS28420 (HF574_29155) 9535..9780 - 246 WP_032440458.1 hypothetical protein -
HF574_RS28425 (HF574_29160) 10425..11912 + 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11970 11970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T205949 WP_071177730.1 NZ_CP076551:c8087-7773 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

>T205949 NZ_CP101937:c2199059-2198883 [Bacillus subtilis]
GTGCTTGAGAAAATGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT205949 WP_000093040.1 NZ_CP076551:c8353-8075 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp

>AT205949 NZ_CP101937:2198842-2198942 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References