Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 2995328..2996001 Replicon chromosome
Accession NZ_CP076547
Organism Subtercola sp. PAMC28395

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KPL76_RS13700 Protein ID WP_253202055.1
Coordinates 2995328..2995765 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KPL76_RS13705 Protein ID WP_216334044.1
Coordinates 2995762..2996001 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPL76_RS13670 (KPL76_13670) 2990544..2991065 - 522 WP_216334036.1 hypothetical protein -
KPL76_RS13675 (KPL76_13675) 2991212..2991571 + 360 WP_216334037.1 PadR family transcriptional regulator -
KPL76_RS13680 (KPL76_13680) 2991574..2991933 + 360 WP_216334038.1 DUF1048 domain-containing protein -
KPL76_RS13685 (KPL76_13685) 2991959..2992423 - 465 WP_216334039.1 phage tail protein -
KPL76_RS13690 (KPL76_13690) 2992527..2992988 - 462 WP_216334040.1 hypothetical protein -
KPL76_RS13695 (KPL76_13695) 2993218..2994810 - 1593 WP_216334042.1 isocitrate lyase -
KPL76_RS13700 (KPL76_13700) 2995328..2995765 - 438 WP_253202055.1 type II toxin-antitoxin system VapC family toxin Toxin
KPL76_RS13705 (KPL76_13705) 2995762..2996001 - 240 WP_216334044.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KPL76_RS13710 (KPL76_13710) 2996110..2997186 - 1077 WP_205107885.1 redox-regulated ATPase YchF -
KPL76_RS13715 (KPL76_13715) 2997303..2998811 - 1509 WP_253202056.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
KPL76_RS13720 (KPL76_13720) 2999051..3000601 + 1551 WP_216334052.1 DNA recombination protein RmuC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-127)

Antitoxin

SpoVT-AbrB domain

(3-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15391.37 Da        Isoelectric Point: 6.3754

>T205948 WP_253202055.1 NZ_CP076547:c2995765-2995328 [Subtercola sp. PAMC28395]
VIPQPRYALDTSVSVPLLMKAHDAHDVVSAWAAGRVLGLSGHALVETYSVLTRLPGDSRVDSADAVLLIDDNFPAHFALS
AEATSTSHRELARHGVSGGATYDGLVALAAREHEAVLVTRDARARQTYEALGVKVEIITVPSVSR

Download         Length: 438 bp

>T205948 NZ_CP101937:c2198864-2198613 [Bacillus subtilis]
ATGAACTTCTCCTTTAGTTCCTACCCATATTATAACATGATCAAGCACATTGCAAACATGAAACGATTCTCATTATGGTT
TACCCATATCACATTCATTGGCTTATTCTTAATGTTTCAACTCATCAAAGATTACTTCAGCAGCGAAGGACAGGCGCTAA
TCAACACAATTTTTGTTGTCACATGTATCATTGCCATATTGTTATGGATCATCTATTGTGTATTCCTTAAACTAAGAAAC
AAGTCACACTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8101.10 Da        Isoelectric Point: 4.9987

>AT205948 WP_216334044.1 NZ_CP076547:c2996001-2995762 [Subtercola sp. PAMC28395]
MEATIDSGGRLLLPKSLRDALGLGPGSKVDVSAYGGGLQVTPGGRTARLERGEDGRLVASSETSVSDDVLFALIDSGRK

Download         Length: 240 bp

>AT205948 NZ_CP101937:2198842-2198942 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References