Detailed information of TA system TA205946

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 121743..122302
• Replicon: chromosome
• Accession: NZ_CP076545
• Organism: Collinsella sp. zg1085

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KPC83_RS00555
• Protein ID: WP_216278660.1
• Coordinates: 122024..122302 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KPC83_RS00550
• Protein ID: WP_216278659.1
• Coordinates: 121743..122024 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KPC83_RS00535 (KPC83_00535)	117295..119079	+	1785	Protein_102	ATP-dependent zinc metalloprotease FtsH	-
KPC83_RS00540 (KPC83_00540)	119515..120702	+	1188	WP_216278657.1	pyridoxal phosphate-dependent aminotransferase	-
KPC83_RS00545 (KPC83_00545)	120823..121623	+	801	WP_216278658.1	phosphatase	-
KPC83_RS00550 (KPC83_00550)	121743..122024	+	282	WP_216278659.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KPC83_RS00555 (KPC83_00555)	122024..122302	+	279	WP_216278660.1	type II toxin-antitoxin system YafQ family toxin	Toxin
KPC83_RS00560 (KPC83_00560)	122397..122990	-	594	WP_216278661.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
KPC83_RS00565 (KPC83_00565)	123168..123485	+	318	WP_216278662.1	hypothetical protein	-
KPC83_RS00570 (KPC83_00570)	123511..125067	+	1557	WP_216278663.1	recombinase family protein	-
KPC83_RS00575 (KPC83_00575)	125072..125500	+	429	WP_216278664.1	recombinase family protein	-
KPC83_RS00580 (KPC83_00580)	125488..127053	+	1566	WP_216278666.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-67)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10793.64 Da
• Isoelectric Point: 9.4319

>T205946 WP_216278660.1 NZ_CP076545:122024-122302 [Collinsella sp. zg1085]
MAHYEIKFSALFRKQLKAAKKRGKVLTKLQKIIDLLADDTMLPAKYRDHALEGRWVNHRECHIEPDWLLIYYKQEDVLVL
TLVATGSHSDLF

Nucleotide

• Length: 279 bp

>T205946 NZ_CP101937:c1328337-1327591 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATTCGGAAAACTTGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATATGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10408.95 Da
• Isoelectric Point: 4.8427

>AT205946 WP_216278659.1 NZ_CP076545:121743-122024 [Collinsella sp. zg1085]
MATTNISIRMEESLKKEADQLFNEMGMNISTAFNIFVRRAIRERAIPFHISLGELNHETIAAMLEAERIAKDPNIPSYVT
AKEALAAALCEDN

Nucleotide

• Length: 282 bp

>AT205946 NZ_CP101937:c1327591-1327421 [Bacillus subtilis]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA