Detailed information of TA system TA205943

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1311295..1311839
• Replicon: chromosome
• Accession: NZ_CP076534
• Organism: Xanthomonas arboricola pv. corylina strain IVIA 3978

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KPG65_RS05405
• Protein ID: WP_228960823.1
• Coordinates: 1311570..1311839 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2N7V9L6
• Locus tag: KPG65_RS05400
• Protein ID: WP_016902922.1
• Coordinates: 1311295..1311552 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KPG65_RS05385 (KPG65_05385)	1306403..1307911	-	1509	WP_249452686.1	ribonuclease H-like domain-containing protein	-
KPG65_RS05390 (KPG65_05390)	1307908..1310403	-	2496	WP_016904859.1	DEAD/DEAH box helicase	-
KPG65_RS05395 (KPG65_05395)	1310577..1311239	+	663	WP_039511099.1	hemolysin III family protein	-
KPG65_RS05400 (KPG65_05400)	1311295..1311552	+	258	WP_016902922.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KPG65_RS05405 (KPG65_05405)	1311570..1311839	+	270	WP_228960823.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KPG65_RS05410 (KPG65_05410)	1311958..1312479	-	522	WP_016902924.1	hypothetical protein	-
KPG65_RS05415 (KPG65_05415)	1312649..1312999	-	351	WP_232618369.1	helix-turn-helix domain-containing protein	-
KPG65_RS05420 (KPG65_05420)	1313025..1313243	+	219	WP_230673957.1	YciI family protein	-
KPG65_RS05425 (KPG65_05425)	1313403..1314494	-	1092	WP_039815611.1	ATP-grasp fold amidoligase family protein	-
KPG65_RS05430 (KPG65_05430)	1314951..1315664	+	714	WP_053046149.1	hypothetical protein	-
KPG65_RS05435 (KPG65_05435)	1315675..1316568	-	894	WP_053046150.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1311295..1329474	18179

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-80)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10221.75 Da
• Isoelectric Point: 10.1539

>T205943 WP_228960823.1 NZ_CP076534:1311570-1311839 [Xanthomonas arboricola pv. corylina]
VADLDAIADYIALEDAAAAAALVRRVFAHVEQLAEHPESGSRPQELKRSRYRQIVEPPCRVFYRVDGQRVVVVHVMRSER
LLRKNRLSR

Nucleotide

• Length: 270 bp

>T205943 NZ_CP101936:525832-526182 [Bacillus subtilis subsp. subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9704.23 Da
• Isoelectric Point: 8.6056

>AT205943 WP_016902922.1 NZ_CP076534:1311295-1311552 [Xanthomonas arboricola pv. corylina]
MRTELVTTLKRQATELLADVERDKEPILITQHGLPSAYLVDVASYERMQQRMAILEGIARGEMAVAEGRSLSHEQAKQRL
ARWLK

Nucleotide

• Length: 258 bp

>AT205943 NZ_CP101936:525546-525827 [Bacillus subtilis subsp. subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Structures

Antitoxin

• AlphaFold DB: A0A2N7V9L6