205940

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 527948..528584 Replicon chromosome
Accession NZ_CP076532
Organism Bacillus sp. JNUCC-24

Toxin (Protein)


Gene name mazF Uniprot ID A0A0P7G713
Locus tag JNUCC24_RS02515 Protein ID WP_024425388.1
Coordinates 528234..528584 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag JNUCC24_RS02510 Protein ID WP_003214273.1
Coordinates 527948..528229 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNUCC24_RS02490 (JNUCC24_02490) 524094..524699 - 606 WP_103132679.1 rhomboid family intramembrane serine protease -
JNUCC24_RS02495 (JNUCC24_02495) 524794..525159 + 366 WP_041089202.1 holo-ACP synthase -
JNUCC24_RS02500 (JNUCC24_02500) 525320..526336 + 1017 WP_087975235.1 outer membrane lipoprotein-sorting protein -
JNUCC24_RS02505 (JNUCC24_02505) 526478..527653 + 1176 WP_103132680.1 alanine racemase -
JNUCC24_RS02510 (JNUCC24_02510) 527948..528229 + 282 WP_003214273.1 hypothetical protein Antitoxin
JNUCC24_RS02515 (JNUCC24_02515) 528234..528584 + 351 WP_024425388.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
JNUCC24_RS02520 (JNUCC24_02520) 528701..529531 + 831 WP_044334717.1 RsbT co-antagonist protein RsbRA -
JNUCC24_RS02525 (JNUCC24_02525) 529536..529904 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
JNUCC24_RS02530 (JNUCC24_02530) 529907..530308 + 402 WP_024425390.1 anti-sigma regulatory factor -
JNUCC24_RS02535 (JNUCC24_02535) 530319..531326 + 1008 WP_216100091.1 PP2C family protein-serine/threonine phosphatase -
JNUCC24_RS02540 (JNUCC24_02540) 531386..531715 + 330 WP_024425392.1 anti-sigma factor antagonist -
JNUCC24_RS02545 (JNUCC24_02545) 531712..532200 + 489 WP_024425393.1 anti-sigma B factor RsbW -
JNUCC24_RS02550 (JNUCC24_02550) 532166..532954 + 789 WP_024427378.1 RNA polymerase sigma factor SigB -
JNUCC24_RS02555 (JNUCC24_02555) 532954..533553 + 600 WP_024427379.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8891

>T205940 WP_024425388.1 NZ_CP076532:528234-528584 [Bacillus sp. JNUCC-24]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

>T205940 NZ_CP101932:1393742-1394488 [Bacillus subtilis subsp. natto]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGGAAAACTTGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATACGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTACCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAACTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCCTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCCTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT205940 WP_003214273.1 NZ_CP076532:527948-528229 [Bacillus sp. JNUCC-24]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp

>AT205940 NZ_CP101932:1394488-1394658 [Bacillus subtilis subsp. natto]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7G713

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References