Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4061064..4061683 Replicon chromosome
Accession NZ_CP076518
Organism Klebsiella pneumoniae strain K186

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KNW01_RS20080 Protein ID WP_002892050.1
Coordinates 4061465..4061683 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KNW01_RS20075 Protein ID WP_002892066.1
Coordinates 4061064..4061438 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KNW01_RS20065 (KNW01_20065) 4056216..4057409 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KNW01_RS20070 (KNW01_20070) 4057432..4060578 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KNW01_RS20075 (KNW01_20075) 4061064..4061438 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KNW01_RS20080 (KNW01_20080) 4061465..4061683 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KNW01_RS20085 (KNW01_20085) 4061842..4062408 + 567 WP_002892030.1 maltose O-acetyltransferase -
KNW01_RS20090 (KNW01_20090) 4062380..4062520 - 141 WP_004147370.1 hypothetical protein -
KNW01_RS20095 (KNW01_20095) 4062541..4063011 + 471 WP_002892026.1 YlaC family protein -
KNW01_RS20100 (KNW01_20100) 4062986..4064437 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KNW01_RS20105 (KNW01_20105) 4064538..4065236 + 699 WP_002892021.1 GNAT family protein -
KNW01_RS20110 (KNW01_20110) 4065233..4065373 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KNW01_RS20115 (KNW01_20115) 4065373..4065636 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T205902 WP_002892050.1 NZ_CP076518:4061465-4061683 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T205902 NZ_CP101922:2593870-2593977 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGAGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT205902 WP_002892066.1 NZ_CP076518:4061064-4061438 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT205902 NZ_CP101922:c2593823-2593757 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References