Detailed information of TA system TA205888

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 1987875..1988400
• Replicon: chromosome
• Accession: NZ_CP076517
• Organism: Streptococcus suis strain 39565

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G7SEL6
• Locus tag: KPA27_RS09680
• Protein ID: WP_014638724.1
• Coordinates: 1987875..1988204 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: KPA27_RS09685
• Protein ID: WP_238492611.1
• Coordinates: 1988194..1988400 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KPA27_RS09660 (KPA27_09660)	1983225..1984955	-	1731	WP_041179291.1	membrane protein	-
KPA27_RS09665 (KPA27_09665)	1985158..1986030	-	873	WP_014638721.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
KPA27_RS09670 (KPA27_09670)	1986208..1987377	-	1170	WP_014638722.1	hypothetical protein	-
KPA27_RS09675 (KPA27_09675)	1987394..1987777	-	384	WP_014638723.1	DUF2513 domain-containing protein	-
KPA27_RS09680 (KPA27_09680)	1987875..1988204	-	330	WP_014638724.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KPA27_RS09685 (KPA27_09685)	1988194..1988400	-	207	WP_238492611.1	toxin-antitoxin system antitoxin subunit	Antitoxin
KPA27_RS09690 (KPA27_09690)	1988579..1988947	-	369	WP_024401195.1	hypothetical protein	-
KPA27_RS09695 (KPA27_09695)	1988940..1989509	-	570	WP_105105440.1	ribonuclease M5	-
KPA27_RS09700 (KPA27_09700)	1989493..1990275	-	783	WP_105105439.1	TatD family hydrolase	-
KPA27_RS09705 (KPA27_09705)	1990382..1990519	-	138	WP_002939016.1	50S ribosomal protein L34	-
KPA27_RS09710 (KPA27_09710)	1990687..1991682	-	996	WP_024395756.1	RNA-binding cell elongation regulator Jag/EloR	-
KPA27_RS09715 (KPA27_09715)	1991702..1992514	-	813	WP_202847568.1	YidC/Oxa1 family membrane protein insertase	-
KPA27_RS09720 (KPA27_09720)	1992498..1992857	-	360	WP_004194560.1	ribonuclease P protein component	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-96)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12607.51 Da
• Isoelectric Point: 5.7640

>T205888 WP_014638724.1 NZ_CP076517:c1988204-1987875 [Streptococcus suis]
MEFESYSVILAPAVEKELADIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVIGKD
YIALYRVVEKEVRVGHLFATKSDYVKLLK

Nucleotide

• Length: 330 bp

>T205888 NZ_CP101921:c4291444-4291271 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7816.90 Da
• Isoelectric Point: 3.9249

>AT205888 WP_238492611.1 NZ_CP076517:c1988400-1988194 [Streptococcus suis]
MNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEAGQGISLEIVKEKYGI

Nucleotide

• Length: 207 bp

>AT205888 NZ_CP101921:c4291768-4291472 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCACTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: G7SEL6