Detailed information of TA system TA205887

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1511105..1511753
• Replicon: chromosome
• Accession: NZ_CP076517
• Organism: Streptococcus suis strain 39565

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KPA27_RS07510
• Protein ID: WP_044679833.1
• Coordinates: 1511592..1511753 (-)
• Length: 54 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G7SGM2
• Locus tag: KPA27_RS07505
• Protein ID: WP_014637654.1
• Coordinates: 1511105..1511554 (-)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KPA27_RS07490 (KPA27_07490)	1506763..1508694	-	1932	WP_202847630.1	C69 family dipeptidase	-
KPA27_RS07495 (KPA27_07495)	1508887..1509747	-	861	WP_044762617.1	SAM-dependent methyltransferase TehB	-
KPA27_RS07500 (KPA27_07500)	1509901..1510944	+	1044	WP_202847719.1	alcohol dehydrogenase catalytic domain-containing protein	-
KPA27_RS07505 (KPA27_07505)	1511105..1511554	-	450	WP_014637654.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KPA27_RS07510 (KPA27_07510)	1511592..1511753	-	162	WP_044679833.1	type II toxin-antitoxin system HicA family toxin	Toxin
KPA27_RS07515 (KPA27_07515)	1512140..1512358	-	219	WP_228475258.1	hypothetical protein	-
KPA27_RS07520 (KPA27_07520)	1512669..1513526	-	858	WP_052502457.1	ABC transporter ATP-binding protein	-
KPA27_RS07525 (KPA27_07525)	1513528..1514211	-	684	WP_044679832.1	hypothetical protein	-
KPA27_RS07530 (KPA27_07530)	1514614..1515081	-	468	WP_014637647.1	SsrA-binding protein SmpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (1-52)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 5807.85 Da
• Isoelectric Point: 10.9132

>T205887 WP_044679833.1 NZ_CP076517:c1511753-1511592 [Streptococcus suis]
MVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Nucleotide

• Length: 162 bp

>T205887 NZ_CP101921:c4188521-4188171 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16664.69 Da
• Isoelectric Point: 3.9458

>AT205887 WP_014637654.1 NZ_CP076517:c1511554-1511105 [Streptococcus suis]
MLVTYPALFYFDDTDGANAPYFVTFPDFEYSATQGEDMADAMAMASDWLGMNLADYIENGRDIPTPSSINTLSLVDNNPF
RNEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Nucleotide

• Length: 450 bp

>AT205887 NZ_CP101921:c4188766-4188515 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGAGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Antitoxin

• AlphaFold DB: G7SGM2