Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1010374..1010875 Replicon chromosome
Accession NZ_CP076517
Organism Streptococcus suis strain 39565

Toxin (Protein)


Gene name relE Uniprot ID G7SDZ6
Locus tag KPA27_RS05165 Protein ID WP_014637925.1
Coordinates 1010609..1010875 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A116L3F7
Locus tag KPA27_RS05160 Protein ID WP_024385716.1
Coordinates 1010374..1010625 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPA27_RS05135 (KPA27_05135) 1005702..1006867 + 1166 Protein_969 ATP-grasp domain-containing protein -
KPA27_RS05140 (KPA27_05140) 1007008..1007148 + 141 WP_044683303.1 hypothetical protein -
KPA27_RS05145 (KPA27_05145) 1007161..1007532 + 372 WP_202847704.1 NisI/SpaI family lantibiotic immunity lipoprotein -
KPA27_RS05150 (KPA27_05150) 1007560..1008312 + 753 WP_015646831.1 ATP-binding cassette domain-containing protein -
KPA27_RS05155 (KPA27_05155) 1008313..1010283 + 1971 WP_202847703.1 ABC transporter permease -
KPA27_RS05160 (KPA27_05160) 1010374..1010625 + 252 WP_024385716.1 DUF6290 family protein Antitoxin
KPA27_RS05165 (KPA27_05165) 1010609..1010875 + 267 WP_014637925.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KPA27_RS05170 (KPA27_05170) 1010914..1011582 + 669 WP_024413648.1 response regulator transcription factor -
KPA27_RS05175 (KPA27_05175) 1011579..1012520 + 942 WP_024413647.1 sensor histidine kinase -
KPA27_RS05180 (KPA27_05180) 1012701..1014209 + 1509 WP_202847702.1 phosphomannomutase/phosphoglucomutase -
KPA27_RS05185 (KPA27_05185) 1014272..1015342 - 1071 WP_044769194.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10345.99 Da        Isoelectric Point: 10.7260

>T205884 WP_014637925.1 NZ_CP076517:1010609-1010875 [Streptococcus suis]
MKTSYKLVPTGRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

>T205884 NZ_CP101921:3536397-3536615 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9296.46 Da        Isoelectric Point: 3.6675

>AT205884 WP_024385716.1 NZ_CP076517:1010374-1010625 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALAEYEADLANGIEPISWEEMLEDLGLTDE
DQL

Download         Length: 252 bp

>AT205884 NZ_CP101921:3535997-3536371 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7SDZ6

Antitoxin

Source ID Structure
AlphaFold DB A0A116L3F7

References