Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 898810..899287 Replicon chromosome
Accession NC_002952
Organism Staphylococcus aureus subsp. aureus MRSA252

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAR_RS04345 Protein ID WP_000052076.1
Coordinates 898810..898998 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAR_RS04350 Protein ID WP_001059690.1
Coordinates 899027..899287 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAR_RS04315 894763..895320 + 558 WP_000824491.1 hypothetical protein -
SAR_RS04320 895661..896347 + 687 WP_001643461.1 thermonuclease family protein -
SAR_RS04325 896704..896904 + 201 WP_001059082.1 cold-shock protein -
SAR_RS04330 897401..897619 - 219 WP_000005879.1 hypothetical protein -
SAR_RS04335 897681..897965 - 285 WP_001004401.1 hypothetical protein -
SAR_RS04340 898053..898622 - 570 WP_001106663.1 hypothetical protein -
SAR_RS04345 898810..898998 - 189 WP_000052076.1 hypothetical protein Toxin
SAR_RS04350 899027..899287 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAR_RS04355 899628..899831 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAR_RS04360 899828..900064 - 237 WP_000368687.1 hypothetical protein -
SAR_RS04365 900289..900870 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
SAR_RS04370 900943..901560 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
SAR_RS04375 901716..902210 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAR_RS04380 902609..903031 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
SAR_RS04385 903179..903895 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T20587 WP_000052076.1 NC_002952:c898998-898810 [Staphylococcus aureus subsp. aureus MRSA252]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T20587 NC_002952:c898998-898810 [Staphylococcus aureus subsp. aureus MRSA252]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT20587 WP_001059690.1 NC_002952:c899287-899027 [Staphylococcus aureus subsp. aureus MRSA252]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT20587 NC_002952:c899287-899027 [Staphylococcus aureus subsp. aureus MRSA252]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References