Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ImmA-IrrE/HTH_26(antitoxin) |
| Location | 974694..975392 | Replicon | chromosome |
| Accession | NZ_CP076498 | ||
| Organism | Enterococcus faecalis strain UAMS_EL53 | ||
Toxin (Protein)
| Gene name | IrrE | Uniprot ID | A0A059N529 |
| Locus tag | KPU58_RS04925 | Protein ID | WP_002373917.1 |
| Coordinates | 974694..975038 (-) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | ImmA | Uniprot ID | - |
| Locus tag | KPU58_RS04930 | Protein ID | WP_002388206.1 |
| Coordinates | 975057..975392 (-) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KPU58_RS04905 (971930) | 971930..972079 | + | 150 | WP_002356321.1 | 50S ribosomal protein L33 | - |
| KPU58_RS04910 (972182) | 972182..973363 | - | 1182 | WP_002365138.1 | site-specific integrase | - |
| KPU58_RS04915 (973518) | 973518..974249 | - | 732 | WP_010706861.1 | potassium channel family protein | - |
| KPU58_RS04920 (974267) | 974267..974665 | - | 399 | WP_010706860.1 | hypothetical protein | - |
| KPU58_RS04925 (974694) | 974694..975038 | - | 345 | WP_002373917.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| KPU58_RS04930 (975057) | 975057..975392 | - | 336 | WP_002388206.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| KPU58_RS04935 (975684) | 975684..975866 | + | 183 | WP_002388205.1 | hypothetical protein | - |
| KPU58_RS04940 (975879) | 975879..976217 | + | 339 | WP_010706859.1 | hypothetical protein | - |
| KPU58_RS04945 (976280) | 976280..976459 | + | 180 | WP_229202013.1 | DUF2829 domain-containing protein | - |
| KPU58_RS04950 (976477) | 976477..976746 | + | 270 | WP_002365131.1 | hypothetical protein | - |
| KPU58_RS04955 (976781) | 976781..976951 | + | 171 | WP_010706857.1 | hypothetical protein | - |
| KPU58_RS04960 (976952) | 976952..977368 | + | 417 | WP_002417286.1 | hypothetical protein | - |
| KPU58_RS04965 (977455) | 977455..977754 | + | 300 | WP_010706856.1 | hypothetical protein | - |
| KPU58_RS04970 (977751) | 977751..977975 | + | 225 | WP_002367281.1 | hypothetical protein | - |
| KPU58_RS04975 (977978) | 977978..978334 | + | 357 | WP_010706855.1 | hypothetical protein | - |
| KPU58_RS04980 (978427) | 978427..979398 | + | 972 | WP_010706854.1 | RecT family recombinase | - |
| KPU58_RS04985 (979361) | 979361..980176 | + | 816 | WP_010706853.1 | PD-(D/E)XK nuclease-like domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 972182..1022898 | 50716 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13594.61 Da Isoelectric Point: 5.6177
>T205867 WP_002373917.1 NZ_CP076498:c975038-974694 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEIYLK
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEIYLK
Download Length: 345 bp
>T205867 NZ_CP101920:c4871473-4871162 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTATTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTATTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12842.51 Da Isoelectric Point: 5.2926
>AT205867 WP_002388206.1 NZ_CP076498:c975392-975057 [Enterococcus faecalis]
MTVFDRIKLLAKERGKSLNRIEEELGLPKNVLYRMKTSDNPTKDRLETLANYFDVSVDYLLGRTDNTKATDEKKSDDLDD
VLDNVMSFDGKPLDDHDREVIRAYLKGRFGK
MTVFDRIKLLAKERGKSLNRIEEELGLPKNVLYRMKTSDNPTKDRLETLANYFDVSVDYLLGRTDNTKATDEKKSDDLDD
VLDNVMSFDGKPLDDHDREVIRAYLKGRFGK
Download Length: 336 bp
>AT205867 NZ_CP101920:c4871161-4870871 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|