205834

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 41122..41656 Replicon plasmid pUAMSEL1
Accession NZ_CP076494
Organism Enterococcus faecalis strain UAMS_EL54

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag KPU55_RS15185 Protein ID WP_002360769.1
Coordinates 41122..41397 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag KPU55_RS15190 Protein ID WP_002369771.1
Coordinates 41390..41656 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPU55_RS15160 (36319) 36319..37047 - 729 WP_002368105.1 hypothetical protein -
KPU55_RS15165 (37697) 37697..38956 - 1260 WP_002368103.1 PcfJ domain-containing protein -
KPU55_RS15170 (38956) 38956..39735 - 780 WP_002368102.1 Cas9 inhibitor AcrIIA9 family protein -
KPU55_RS15175 (39966) 39966..40112 - 147 WP_002368101.1 DpnD/PcfM family protein -
KPU55_RS15180 (40134) 40134..40319 - 186 WP_002368099.1 hypothetical protein -
KPU55_RS15185 (41122) 41122..41397 - 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
KPU55_RS15190 (41390) 41390..41656 - 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KPU55_RS15195 (41767) 41767..42351 - 585 WP_002368095.1 thermonuclease family protein -
KPU55_RS15200 (42375) 42375..42791 - 417 WP_002368093.1 single-stranded DNA-binding protein -
KPU55_RS15205 (42889) 42889..43383 - 495 WP_002368092.1 DnaJ domain-containing protein -
KPU55_RS15210 (43416) 43416..43682 - 267 WP_002368091.1 hypothetical protein -
KPU55_RS15215 (44274) 44274..44762 - 489 WP_002368088.1 hypothetical protein -
KPU55_RS15220 (44768) 44768..45553 - 786 WP_000803546.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-III / ant(6)-Ia / erm(B) cylI / cylA / cylB / cylM / cylS / cylL / cylR1 / cylR2 1..119714 119714


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-86)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T205834 WP_002360769.1 NZ_CP076494:c41397-41122 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

>T205834 NZ_CP101915:2648689-2648796 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9772.09 Da        Isoelectric Point: 4.4791

>AT205834 WP_002369771.1 NZ_CP076494:c41656-41390 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp

>AT205834 NZ_CP101915:c2648642-2648576 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References