205797

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 116562..117096 Replicon plasmid pUAMSEL1
Accession NZ_CP076489
Organism Enterococcus faecalis strain UAMS_EL56

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag KPU60_RS15625 Protein ID WP_002360769.1
Coordinates 116562..116837 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag KPU60_RS15630 Protein ID WP_002369771.1
Coordinates 116830..117096 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPU60_RS15600 (111759) 111759..112487 - 729 WP_002368105.1 hypothetical protein -
KPU60_RS15605 (113137) 113137..114396 - 1260 WP_002368103.1 PcfJ domain-containing protein -
KPU60_RS15610 (114396) 114396..115175 - 780 WP_002368102.1 Cas9 inhibitor AcrIIA9 family protein -
KPU60_RS15615 (115406) 115406..115552 - 147 WP_002368101.1 DpnD/PcfM family protein -
KPU60_RS15620 (115574) 115574..115759 - 186 WP_002368099.1 hypothetical protein -
KPU60_RS15625 (116562) 116562..116837 - 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
KPU60_RS15630 (116830) 116830..117096 - 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KPU60_RS15635 (117207) 117207..117791 - 585 WP_002368095.1 thermonuclease family protein -
KPU60_RS15640 (117815) 117815..118231 - 417 WP_002368093.1 single-stranded DNA-binding protein -
KPU60_RS15645 (118329) 118329..118823 - 495 WP_002368092.1 DnaJ domain-containing protein -
KPU60_RS15650 (118856) 118856..119122 - 267 WP_002368091.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-III / ant(6)-Ia / erm(B) cylI / cylA / cylB / cylM / cylS / cylL / cylR1 / cylR2 1..119713 119713


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-86)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T205797 WP_002360769.1 NZ_CP076489:c116837-116562 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

>T205797 NZ_CP101910:1045903-1046199 [Pseudomonas putida]
ATGAGCGAAAAATTGATCCCGTTTGATATGGCAGCCTTGTTGAGCAGCGATGAGGCAATCAGTGAATACCTTAGCCAGGT
GCTATCAGATGGCGATACCGAGGAAATCATTCGAGCACTTGGACATATCGCTCGTGCACGGGGCATGACACATATTGCTA
CGGAGAGTGGGCTGGGTAGAGAAAGCCTGTACAAGGCGCTGAGCCCTGGCGCGAAGCCTCGTTTTGACACGGTATTGAGG
GTCATTCGTGCTCTGGGGGTGGACCTTCTCGTTCAGCCACAGGCAATGACCCGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9772.09 Da        Isoelectric Point: 4.4791

>AT205797 WP_002369771.1 NZ_CP076489:c117096-116830 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp

>AT205797 NZ_CP101910:1045613-1045906 [Pseudomonas putida]
ATGTTTCTCGTTGAACAGACGGAAAGCTTTGCCGCTTGCCTATCGAGCTTGAGAGATTTGAGGGCCAGGCTGGCGATAGG
TCGTAGGCTGGAGCGAGCAGCGGGGGGCAATCTTGGTGACTTCAAGTGGCTTGGAGGCGATATTGGTGAGCTTCGCATCG
ACGTAGCTGCCGGTTATCGCGTCTATTTCACGCAAAAGGGGGAGAGGTTGGTTTTACTGCTGGTCGGCGGCGACAAGTCC
ACCCAGGCCGCCGACATCCTCAAAGCCAGAAAGCTGCTGAAGGAGATGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References