Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-epsilon |
| Location | 25398..26067 | Replicon | plasmid pUAMSEL1 |
| Accession | NZ_CP076489 | ||
| Organism | Enterococcus faecalis strain UAMS_EL56 | ||
Toxin (Protein)
| Gene name | zeta | Uniprot ID | - |
| Locus tag | KPU60_RS15085 | Protein ID | WP_010708525.1 |
| Coordinates | 25398..25793 (-) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | epsilon | Uniprot ID | Q9AL01 |
| Locus tag | KPU60_RS15090 | Protein ID | WP_002331065.1 |
| Coordinates | 25795..26067 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KPU60_RS15050 (20609) | 20609..20905 | + | 297 | WP_002387528.1 | hypothetical protein | - |
| KPU60_RS15055 (21159) | 21159..21941 | + | 783 | WP_002369746.1 | ParA family protein | - |
| KPU60_RS15060 (21934) | 21934..22290 | + | 357 | WP_002360663.1 | hypothetical protein | - |
| KPU60_RS15065 (22550) | 22550..23563 | + | 1014 | WP_002387529.1 | replication initiator protein A | - |
| KPU60_RS15070 (23694) | 23694..24362 | + | 669 | WP_002383592.1 | type II CAAX endopeptidase family protein | - |
| KPU60_RS15075 (24405) | 24405..24656 | + | 252 | WP_010708530.1 | hypothetical protein | - |
| KPU60_RS15080 (24690) | 24690..25370 | - | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
| KPU60_RS15085 (25398) | 25398..25793 | - | 396 | WP_010708525.1 | zeta toxin family protein | Toxin |
| KPU60_RS15090 (25795) | 25795..26067 | - | 273 | WP_002331065.1 | antitoxin | Antitoxin |
| KPU60_RS15095 (26084) | 26084..26293 | - | 210 | WP_000527318.1 | peptide-binding protein | - |
| KPU60_RS15100 (26392) | 26392..27288 | - | 897 | WP_002334978.1 | AAA family ATPase | - |
| KPU60_RS15105 (27586) | 27586..28158 | - | 573 | WP_001079938.1 | HTH domain-containing protein | - |
| KPU60_RS15110 (28434) | 28434..29228 | - | 795 | WP_001096887.1 | aminoglycoside O-phosphotransferase APH(3')-IIIa | - |
| KPU60_RS15115 (29321) | 29321..29863 | - | 543 | WP_000627290.1 | streptothricin N-acetyltransferase Sat4 | - |
| KPU60_RS15120 (29860) | 29860..30768 | - | 909 | WP_001255866.1 | aminoglycoside nucleotidyltransferase ANT(6)-Ia | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aph(3')-III / ant(6)-Ia / erm(B) | cylI / cylA / cylB / cylM / cylS / cylL / cylR1 / cylR2 | 1..119713 | 119713 | |
| - | inside | IScluster/Tn | aph(3')-III / ant(6)-Ia / erm(B) | - | 24690..34764 | 10074 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14867.86 Da Isoelectric Point: 5.2505
>T205789 WP_010708525.1 NZ_CP076489:c25793-25398 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEALISRLSDQGYNLVIEGFCCKVLNLLSNKVE
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEALISRLSDQGYNLVIEGFCCKVLNLLSNKVE
Download Length: 396 bp
>T205789 NZ_CP101907:3401783-3402151 [Salmonella enterica subsp. enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10733.17 Da Isoelectric Point: 4.4865
>AT205789 WP_002331065.1 NZ_CP076489:c26067-25795 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILNKEKVA
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILNKEKVA
Download Length: 273 bp
>AT205789 NZ_CP101907:3401565-3401786 [Salmonella enterica subsp. enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|