Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ImmA-IrrE/HTH_26(antitoxin) |
| Location | 813291..813989 | Replicon | chromosome |
| Accession | NZ_CP076488 | ||
| Organism | Enterococcus faecalis strain UAMS_EL56 | ||
Toxin (Protein)
| Gene name | IrrE | Uniprot ID | A0A059N529 |
| Locus tag | KPU60_RS04075 | Protein ID | WP_002373917.1 |
| Coordinates | 813291..813635 (-) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | ImmA | Uniprot ID | - |
| Locus tag | KPU60_RS04080 | Protein ID | WP_002388206.1 |
| Coordinates | 813654..813989 (-) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KPU60_RS04055 (810527) | 810527..810676 | + | 150 | WP_002356321.1 | 50S ribosomal protein L33 | - |
| KPU60_RS04060 (810779) | 810779..811960 | - | 1182 | WP_002365138.1 | site-specific integrase | - |
| KPU60_RS04065 (812115) | 812115..812846 | - | 732 | WP_010706861.1 | potassium channel family protein | - |
| KPU60_RS04070 (812864) | 812864..813262 | - | 399 | WP_010706860.1 | hypothetical protein | - |
| KPU60_RS04075 (813291) | 813291..813635 | - | 345 | WP_002373917.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| KPU60_RS04080 (813654) | 813654..813989 | - | 336 | WP_002388206.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| KPU60_RS04085 (814281) | 814281..814463 | + | 183 | WP_002388205.1 | hypothetical protein | - |
| KPU60_RS04090 (814476) | 814476..814814 | + | 339 | WP_010706859.1 | hypothetical protein | - |
| KPU60_RS04095 (814877) | 814877..815056 | + | 180 | WP_229202013.1 | DUF2829 domain-containing protein | - |
| KPU60_RS04100 (815074) | 815074..815343 | + | 270 | WP_002365131.1 | hypothetical protein | - |
| KPU60_RS04105 (815378) | 815378..815548 | + | 171 | WP_010706857.1 | hypothetical protein | - |
| KPU60_RS04110 (815549) | 815549..815965 | + | 417 | WP_002417286.1 | hypothetical protein | - |
| KPU60_RS04115 (816052) | 816052..816351 | + | 300 | WP_010706856.1 | hypothetical protein | - |
| KPU60_RS04120 (816348) | 816348..816572 | + | 225 | WP_002367281.1 | hypothetical protein | - |
| KPU60_RS04125 (816575) | 816575..816931 | + | 357 | WP_010706855.1 | hypothetical protein | - |
| KPU60_RS04130 (817024) | 817024..817995 | + | 972 | WP_010706854.1 | RecT family recombinase | - |
| KPU60_RS04135 (817958) | 817958..818773 | + | 816 | WP_010706853.1 | PD-(D/E)XK nuclease-like domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 810779..861495 | 50716 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13594.61 Da Isoelectric Point: 5.6177
>T205784 WP_002373917.1 NZ_CP076488:c813635-813291 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEIYLK
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEIYLK
Download Length: 345 bp
>T205784 NZ_CP101907:c2355398-2355090 [Salmonella enterica subsp. enterica]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12842.51 Da Isoelectric Point: 5.2926
>AT205784 WP_002388206.1 NZ_CP076488:c813989-813654 [Enterococcus faecalis]
MTVFDRIKLLAKERGKSLNRIEEELGLPKNVLYRMKTSDNPTKDRLETLANYFDVSVDYLLGRTDNTKATDEKKSDDLDD
VLDNVMSFDGKPLDDHDREVIRAYLKGRFGK
MTVFDRIKLLAKERGKSLNRIEEELGLPKNVLYRMKTSDNPTKDRLETLANYFDVSVDYLLGRTDNTKATDEKKSDDLDD
VLDNVMSFDGKPLDDHDREVIRAYLKGRFGK
Download Length: 336 bp
>AT205784 NZ_CP101907:c2355640-2355401 [Salmonella enterica subsp. enterica]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|