Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 890858..891335 Replicon chromosome
Accession NC_002951
Organism Staphylococcus aureus subsp. aureus COL

Toxin (Protein)


Gene name TsaT Uniprot ID A0A0H3K6W0
Locus tag SACOL_RS04440 Protein ID WP_000052077.1
Coordinates 890858..891046 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SACOL_RS04445 Protein ID WP_001059690.1
Coordinates 891075..891335 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SACOL_RS04410 886899..887369 + 471 WP_000824472.1 hypothetical protein -
SACOL_RS04415 887710..888396 + 687 WP_001548082.1 thermonuclease family protein -
SACOL_RS04420 888753..888953 + 201 WP_001059082.1 cold-shock protein -
SACOL_RS04425 889449..889667 - 219 WP_000005886.1 hypothetical protein -
SACOL_RS04430 889729..890013 - 285 WP_001004395.1 hypothetical protein -
SACOL_RS04435 890101..890670 - 570 WP_001106654.1 hypothetical protein -
SACOL_RS04440 890858..891046 - 189 WP_000052077.1 hypothetical protein Toxin
SACOL_RS04445 891075..891335 - 261 WP_001059690.1 hypothetical protein Antitoxin
SACOL_RS04450 891676..891879 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SACOL_RS04455 891876..892112 - 237 WP_000368687.1 hypothetical protein -
SACOL_RS04460 892337..892918 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
SACOL_RS04465 892991..893608 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
SACOL_RS04470 893763..894257 - 495 WP_000569886.1 GNAT family N-acetyltransferase -
SACOL_RS04475 894656..895078 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SACOL_RS04480 895226..895942 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq / seb 885542..918806 33264


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

Antitoxin ParD

(1-58)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7186.87 Da        Isoelectric Point: 9.9971

>T20577 WP_000052077.1 NC_002951:c891046-890858 [Staphylococcus aureus subsp. aureus COL]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTIILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T20577 NC_002951:c891046-890858 [Staphylococcus aureus subsp. aureus COL]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTATCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT20577 WP_001059690.1 NC_002951:c891335-891075 [Staphylococcus aureus subsp. aureus COL]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT20577 NC_002951:c891335-891075 [Staphylococcus aureus subsp. aureus COL]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K6W0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References