Detailed information of TA system TA205717

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 772993..773543
• Replicon: chromosome
• Accession: NZ_CP076458
• Organism: Novisyntrophococcus fermenticellae strain JN500902

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KNL20_RS03540
• Protein ID: WP_230399266.1
• Coordinates: 773262..773543 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KNL20_RS03535
• Protein ID: WP_230399265.1
• Coordinates: 772993..773265 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KNL20_RS03515	768858..769721	+	864	WP_230399261.1	ROK family protein	-
KNL20_RS03520	770166..772136	+	1971	WP_230399262.1	hypothetical protein	-
KNL20_RS03525	772330..772509	+	180	WP_230399263.1	hypothetical protein	-
KNL20_RS03530	772562..772987	+	426	WP_230399264.1	fibronectin type III-like domain-contianing protein	-
KNL20_RS03535	772993..773265	+	273	WP_230399265.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KNL20_RS03540	773262..773543	+	282	WP_230399266.1	type II toxin-antitoxin system YafQ family toxin	Toxin
KNL20_RS03545	774192..774848	-	657	WP_230399267.1	ATP-binding protein	-
KNL20_RS03550	775098..775346	+	249	WP_230399268.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
KNL20_RS03555	775350..775652	+	303	WP_230399269.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KNL20_RS03560	776009..777634	-	1626	WP_230399270.1	IS66 family transposase	-
KNL20_RS03565	777707..778051	-	345	WP_230399271.1	IS66 family insertion sequence element accessory protein TnpB	-
KNL20_RS03570	778041..778448	-	408	WP_230399272.1	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	777707..778051	344

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-88)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10833.70 Da
• Isoelectric Point: 7.3559

>T205717 WP_230399266.1 NZ_CP076458:773262-773543 [Novisyntrophococcus fermenticellae]
MTYQLALTGRFKKGLKRAKKRGLDITLLDFVVEKLIHGLALEQKYRDHDLKGKYVGFRECHIQPDWLLVYLIEDEILTLT
LVDTGTHADLFDM

Nucleotide

• Length: 282 bp

>T205717 NZ_CP101858:c1716683-1716285 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10183.69 Da
• Isoelectric Point: 4.4944

>AT205717 WP_230399265.1 NZ_CP076458:772993-773265 [Novisyntrophococcus fermenticellae]
MATVPTQIRIDEELKKQAMELFGQLGTDISSATNMFLRQCVLRGGLPFNVELPSYKPEVIEAMEEAKRISRDPDTKKYSS
FNAALEDMEL

Nucleotide

• Length: 273 bp

>AT205717 NZ_CP101858:c1716910-1716683 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA