Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4809730..4810246 Replicon chromosome
Accession NZ_CP076453
Organism Klebsiella pneumoniae strain PM27

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KOM10_RS23220 Protein ID WP_002886902.1
Coordinates 4809730..4810014 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KOM10_RS23225 Protein ID WP_002886901.1
Coordinates 4810004..4810246 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOM10_RS23195 (KOM10_23130) 4805126..4805389 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
KOM10_RS23200 (KOM10_23135) 4805519..4805692 + 174 WP_002886906.1 hypothetical protein -
KOM10_RS23205 (KOM10_23140) 4805695..4806438 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KOM10_RS23210 (KOM10_23145) 4806795..4808933 + 2139 WP_004222153.1 anaerobic ribonucleoside-triphosphate reductase -
KOM10_RS23215 (KOM10_23150) 4809262..4809726 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KOM10_RS23220 (KOM10_23155) 4809730..4810014 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KOM10_RS23225 (KOM10_23160) 4810004..4810246 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KOM10_RS23230 (KOM10_23165) 4810324..4812234 - 1911 WP_004152270.1 PRD domain-containing protein -
KOM10_RS23235 (KOM10_23170) 4812257..4813411 - 1155 WP_004178372.1 lactonase family protein -
KOM10_RS23240 (KOM10_23175) 4813478..4814218 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T205710 WP_002886902.1 NZ_CP076453:c4810014-4809730 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T205710 NZ_CP101858:c460395-460201 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT205710 WP_002886901.1 NZ_CP076453:c4810246-4810004 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT205710 NZ_CP101858:460024-460202 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References