Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4105525..4106144 Replicon chromosome
Accession NZ_CP076453
Organism Klebsiella pneumoniae strain PM27

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KOM10_RS19880 Protein ID WP_002892050.1
Coordinates 4105926..4106144 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KOM10_RS19875 Protein ID WP_002892066.1
Coordinates 4105525..4105899 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOM10_RS19865 (KOM10_19810) 4100677..4101870 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KOM10_RS19870 (KOM10_19815) 4101893..4105039 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KOM10_RS19875 (KOM10_19820) 4105525..4105899 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KOM10_RS19880 (KOM10_19825) 4105926..4106144 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KOM10_RS19885 (KOM10_19830) 4106303..4106869 + 567 WP_002892030.1 maltose O-acetyltransferase -
KOM10_RS19890 (KOM10_19835) 4106841..4106981 - 141 WP_004147370.1 hypothetical protein -
KOM10_RS19895 (KOM10_19840) 4107002..4107472 + 471 WP_002892026.1 YlaC family protein -
KOM10_RS19900 (KOM10_19845) 4107447..4108898 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KOM10_RS19905 (KOM10_19850) 4108999..4109697 + 699 WP_002892021.1 GNAT family protein -
KOM10_RS19910 (KOM10_19855) 4109694..4109834 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KOM10_RS19915 (KOM10_19860) 4109834..4110097 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T205708 WP_002892050.1 NZ_CP076453:4105926-4106144 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T205708 NZ_CP101858:c322364-322257 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT205708 WP_002892066.1 NZ_CP076453:4105525-4105899 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT205708 NZ_CP101858:322417-322478 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References