Detailed information of TA system TA205707

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2607512..2609100
• Replicon: chromosome
• Accession: NZ_CP076453
• Organism: Klebsiella pneumoniae strain PM27

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: W9B834
• Locus tag: KOM10_RS12565
• Protein ID: WP_016529318.1
• Coordinates: 2607778..2609100 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KOM10_RS12560
• Protein ID: WP_004176198.1
• Coordinates: 2607512..2607778 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KOM10_RS12535 (KOM10_12525)	2602664..2603587	+	924	WP_016529218.1	LysR family hpxDE operon transcriptional regulator HpxR	-
KOM10_RS12540 (KOM10_12530)	2603568..2604722	-	1155	WP_046043281.1	FAD-dependent urate hydroxylase HpxO	-
KOM10_RS12545 (KOM10_12535)	2605068..2606446	+	1379	Protein_2472	nucleobase:cation symporter-2 family protein	-
KOM10_RS12550 (KOM10_12540)	2606424..2606924	+	501	WP_046043283.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
KOM10_RS12555 (KOM10_12545)	2606921..2607247	+	327	WP_002904788.1	hydroxyisourate hydrolase	-
KOM10_RS12560 (KOM10_12550)	2607512..2607778	+	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KOM10_RS12565 (KOM10_12555)	2607778..2609100	+	1323	WP_016529318.1	type II toxin-antitoxin system HipA family toxin	Toxin
KOM10_RS12570 (KOM10_12560)	2609117..2610409	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
KOM10_RS12575 (KOM10_12565)	2610551..2611555	-	1005	WP_252919363.1	fimbrial protein	-
KOM10_RS12580 (KOM10_12570)	2611543..2614044	-	2502	WP_174893385.1	fimbria/pilus outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49125.44 Da
• Isoelectric Point: 7.5366

>T205707 WP_016529318.1 NZ_CP076453:2607778-2609100 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T205707 NZ_CP101858:c321829-321722 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT205707 WP_004176198.1 NZ_CP076453:2607512-2607778 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT205707 NZ_CP101858:321877-321943 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: W9B834