205691

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 2280462..2281379 Replicon chromosome
Accession NZ_CP076450
Organism Bacillus velezensis strain GMEKP1

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag KOM03_RS11720 Protein ID WP_032866111.1
Coordinates 2280633..2281379 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID -
Locus tag KOM03_RS11715 Protein ID WP_060561801.1
Coordinates 2280462..2280632 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOM03_RS11680 (KOM03_11680) 2275687..2277318 + 1632 WP_060561803.1 pyocin knob domain-containing protein -
KOM03_RS11685 (KOM03_11685) 2277331..2277702 + 372 WP_060561802.1 XkdW family protein -
KOM03_RS11690 (KOM03_11690) 2277707..2277904 + 198 WP_059367156.1 XkdX family protein -
KOM03_RS11695 (KOM03_11695) 2277961..2278721 + 761 Protein_2253 phage portal protein -
KOM03_RS11700 (KOM03_11700) 2278773..2279036 + 264 WP_003154815.1 hemolysin XhlA family protein -
KOM03_RS11705 (KOM03_11705) 2279050..2279313 + 264 WP_003154813.1 phage holin -
KOM03_RS11710 (KOM03_11710) 2279327..2280205 + 879 WP_043021264.1 N-acetylmuramoyl-L-alanine amidase -
KOM03_RS20430 2280240..2280365 - 126 WP_023356844.1 hypothetical protein -
KOM03_RS11715 (KOM03_11715) 2280462..2280632 - 171 WP_060561801.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
KOM03_RS11720 (KOM03_11720) 2280633..2281379 - 747 WP_032866111.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KOM03_RS11725 (KOM03_11725) 2281484..2282483 - 1000 Protein_2260 inorganic phosphate transporter -
KOM03_RS11730 (KOM03_11730) 2282496..2283113 - 618 WP_003154804.1 DUF47 domain-containing protein -
KOM03_RS11735 (KOM03_11735) 2283399..2284715 - 1317 WP_007610842.1 amino acid permease -
KOM03_RS11740 (KOM03_11740) 2285038..2285988 + 951 WP_012117369.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29095.60 Da        Isoelectric Point: 4.7755

>T205691 WP_032866111.1 NZ_CP076450:c2281379-2280633 [Bacillus velezensis]
MLMFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

>T205691 NZ_CP101835:c4944584-4943667 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6690.77 Da        Isoelectric Point: 10.9273

>AT205691 WP_060561801.1 NZ_CP076450:c2280632-2280462 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQLSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp

>AT205691 NZ_CP101835:c4945348-4944590 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References