Detailed information of TA system TA205688

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YefM-YoeB
• Location: 2084933..2085435
• Replicon: chromosome
• Accession: NZ_CP076449
• Organism: Aggregatibacter actinomycetemcomitans strain CU1000N

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2JX79
• Locus tag: KO461_RS10235
• Protein ID: WP_005547296.1
• Coordinates: 2084933..2085184 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S4W640
• Locus tag: KO461_RS10240
• Protein ID: WP_005556313.1
• Coordinates: 2085181..2085435 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KO461_RS10215 (KO461_10205)	2080242..2081432	-	1191	WP_205764620.1	hypothetical protein	-
KO461_RS10220 (KO461_10210)	2081441..2082214	-	774	WP_179287355.1	glycosyltransferase family 25 protein	-
KO461_RS10225 (KO461_10215)	2082348..2083871	+	1524	WP_005565307.1	hypothetical protein	-
KO461_RS10230 (KO461_10220)	2083868..2084824	+	957	WP_061888310.1	polysaccharide pyruvyl transferase family protein	-
KO461_RS10235 (KO461_10225)	2084933..2085184	+	252	WP_005547296.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Toxin
KO461_RS10240 (KO461_10230)	2085181..2085435	+	255	WP_005556313.1	Txe/YoeB family addiction module toxin	Antitoxin
KO461_RS10245 (KO461_10235)	2085448..2086191	+	744	WP_005565311.1	YdcF family protein	-
KO461_RS10250 (KO461_10240)	2086368..2087195	+	828	WP_005556311.1	DNA ligase	-
KO461_RS10255 (KO461_10245)	2087328..2089502	-	2175	WP_005565316.1	DNA helicase II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Antitoxin

• Toxin YoeB (1-84)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9394.66 Da
• Isoelectric Point: 5.0637

>T205688 WP_005547296.1 NZ_CP076449:2084933-2085184 [Aggregatibacter actinomycetemcomitans]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLASIDQLNSGKIIERE
LQE

Nucleotide

• Length: 252 bp

>T205688 NZ_CP101835:4073097-4073315 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 10217.71 Da
• Isoelectric Point: 8.8844

>AT205688 WP_005556313.1 NZ_CP076449:2085181-2085435 [Aggregatibacter actinomycetemcomitans]
MILAWTETAWEDYLYWQQVDKKTLLRINKLIQNITRSPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Nucleotide

• Length: 255 bp

>AT205688 NZ_CP101835:4072696-4073070 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• AlphaFold DB: X2JX79

Antitoxin

• AlphaFold DB: S4W640