Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 2041575..2042167 Replicon chromosome
Accession NZ_CP076449
Organism Aggregatibacter actinomycetemcomitans strain CU1000N

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KO461_RS10015 Protein ID WP_005559852.1
Coordinates 2041868..2042167 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KO461_RS10010 Protein ID WP_005559850.1
Coordinates 2041575..2041871 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KO461_RS09990 (KO461_09975) 2037680..2038660 - 981 WP_042890160.1 oxidoreductase -
KO461_RS09995 (KO461_09980) 2038721..2039200 + 480 WP_005565256.1 Cys-tRNA(Pro) deacylase -
KO461_RS10000 (KO461_09985) 2039504..2040901 - 1398 WP_005565257.1 MATE family efflux transporter -
KO461_RS10005 (KO461_09990) 2040928..2041542 + 615 WP_005565258.1 riboflavin synthase -
KO461_RS10010 (KO461_09995) 2041575..2041871 - 297 WP_005559850.1 putative addiction module antidote protein Antitoxin
KO461_RS10015 (KO461_10000) 2041868..2042167 - 300 WP_005559852.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KO461_RS10020 (KO461_10005) 2042335..2042637 + 303 WP_005545243.1 ribosome assembly RNA-binding protein YhbY -
KO461_RS10025 (KO461_10010) 2042713..2043189 - 477 WP_005542429.1 transcription elongation factor GreA -
KO461_RS10030 (KO461_10015) 2043349..2044791 + 1443 WP_005565260.1 serine-type D-Ala-D-Ala carboxypeptidase -
KO461_RS10035 (KO461_10020) 2044890..2045546 - 657 WP_005565262.1 GTP cyclohydrolase I FolE -
KO461_RS10040 (KO461_10025) 2045675..2046889 + 1215 WP_005559859.1 molybdopterin molybdotransferase MoeA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11419.53 Da        Isoelectric Point: 10.4825

>T205687 WP_005559852.1 NZ_CP076449:c2042167-2041868 [Aggregatibacter actinomycetemcomitans]
MMIQIKTIFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDEGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Download         Length: 300 bp

>T205687 NZ_CP101835:c2749214-2747892 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10853.30 Da        Isoelectric Point: 4.2702

>AT205687 WP_005559850.1 NZ_CP076449:c2041871-2041575 [Aggregatibacter actinomycetemcomitans]
MSEQLKDFDPAEYLSTEEDIQLYLNEVLQENNIELILSALGDIARARNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYAS

Download         Length: 297 bp

>AT205687 NZ_CP101835:c2749480-2749214 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References