Detailed information of TA system TA205685

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-PumB/upstrm_HI1419-dnstrm_HI1420
• Location: 1805761..1806358
• Replicon: chromosome
• Accession: NZ_CP076449
• Organism: Aggregatibacter actinomycetemcomitans strain CU1000N

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KO461_RS08890
• Protein ID: WP_205764597.1
• Coordinates: 1806056..1806358 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: G4A710
• Locus tag: KO461_RS08885
• Protein ID: WP_005556438.1
• Coordinates: 1805761..1806054 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KO461_RS08855 (KO461_08855)	1801402..1801581	+	180	WP_005538158.1	helix-turn-helix domain-containing protein	-
KO461_RS08860 (KO461_08860)	1801691..1802692	-	1002	WP_005538156.1	site-specific integrase	-
KO461_RS08870 (KO461_08870)	1803268..1803678	+	411	WP_005538154.1	CidA/LrgA family protein	-
KO461_RS08875 (KO461_08875)	1803678..1804370	+	693	WP_005565532.1	CidB/LrgB family autolysis modulator	-
KO461_RS08880 (KO461_08880)	1804372..1805724	+	1353	WP_005538151.1	anti-phage deoxyguanosine triphosphatase	-
KO461_RS08885 (KO461_08885)	1805761..1806054	-	294	WP_005556438.1	putative addiction module antidote protein	Antitoxin
KO461_RS08890 (KO461_08890)	1806056..1806358	-	303	WP_205764597.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KO461_RS08895 (KO461_08895)	1806511..1808430	+	1920	WP_205764598.1	ABC transporter ATP-binding protein	-
KO461_RS08900 (KO461_08900)	1808471..1809418	+	948	WP_228414632.1	glycoside hydrolase family 19	-
KO461_RS08905	1809342..1810970	+	1629	WP_228414634.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1797143..1810970	13827

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (47-89)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11471.97 Da
• Isoelectric Point: 5.1767

>T205685 WP_205764597.1 NZ_CP076449:c1806358-1806056 [Aggregatibacter actinomycetemcomitans]
MYIIEETEEFSNWLENLTDELAIVNIVARIERAKLDNFGDHKSVGNGVYEMRITKGKGYRIYYARKGGITYLLILGGDKS
SQEQDIQNAKALWQQIKNGE

Nucleotide

• Length: 303 bp

>T205685 NZ_CP101835:904832-905242 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10694.39 Da
• Isoelectric Point: 6.3545

>AT205685 WP_005556438.1 NZ_CP076449:c1806054-1805761 [Aggregatibacter actinomycetemcomitans]
MTVTTREFDAARYLKNEKMMAMYLETVLEEGTTAEFIQALNTVARAKGMSELAEKTGIGRESLYKTLSSEKPRFDTILKI
ISALGLSLSINAKDAVA

Nucleotide

• Length: 294 bp

>AT205685 NZ_CP101835:904585-904851 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A142FXE9