Detailed information of TA system TA205683

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1372436..1372986
• Replicon: chromosome
• Accession: NZ_CP076449
• Organism: Aggregatibacter actinomycetemcomitans strain CU1000N

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G4A7B4
• Locus tag: KO461_RS06895
• Protein ID: WP_005539226.1
• Coordinates: 1372436..1372702 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KO461_RS06900
• Protein ID: WP_005565436.1
• Coordinates: 1372714..1372986 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KO461_RS06880 (KO461_06870)	1368896..1369309	+	414	WP_005539234.1	hydroxyisourate hydrolase	-
KO461_RS06885 (KO461_06875)	1369503..1370291	+	789	WP_005565431.1	hypothetical protein	-
KO461_RS06890 (KO461_06880)	1370845..1372404	-	1560	WP_005565434.1	glutamine-hydrolyzing GMP synthase	-
KO461_RS06895 (KO461_06885)	1372436..1372702	-	267	WP_005539226.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
KO461_RS06900 (KO461_06890)	1372714..1372986	-	273	WP_005565436.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KO461_RS06905 (KO461_06895)	1373241..1374593	-	1353	WP_005551801.1	anaerobic C4-dicarboxylate transporter DcuC	-
KO461_RS06910 (KO461_06900)	1375270..1375473	+	204	WP_005544186.1	IS3 family transposase	-
KO461_RS06915 (KO461_06905)	1375480..1375614	+	135	WP_005544187.1	hypothetical protein	-
KO461_RS06920 (KO461_06910)	1375645..1375839	+	195	WP_005551806.1	integrase core domain-containing protein	-
KO461_RS06925 (KO461_06915)	1375971..1376453	-	483	WP_005552667.1	redoxin family protein	-
KO461_RS06930 (KO461_06920)	1376468..1377109	-	642	WP_005546457.1	cytochrome c biogenesis protein CcdA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-80)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10502.03 Da
• Isoelectric Point: 7.2393

>T205683 WP_005539226.1 NZ_CP076449:c1372702-1372436 [Aggregatibacter actinomycetemcomitans]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLVLIYKIEADTLYFARL
NSHSEVFK

Nucleotide

• Length: 267 bp

>T205683 NZ_CP101835:350582-350929 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10094.47 Da
• Isoelectric Point: 4.9621

>AT205683 WP_005565436.1 NZ_CP076449:c1372986-1372714 [Aggregatibacter actinomycetemcomitans]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKICDLSK

Nucleotide

• Length: 273 bp

>AT205683 NZ_CP101835:350929-351228 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Toxin

• AlphaFold DB: A0A142FY83