Detailed information of TA system TA205682

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1339057..1339591
• Replicon: chromosome
• Accession: NZ_CP076449
• Organism: Aggregatibacter actinomycetemcomitans strain CU1000N

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A142FYB7
• Locus tag: KO461_RS06725
• Protein ID: WP_005540089.1
• Coordinates: 1339057..1339347 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KO461_RS06730
• Protein ID: WP_005565410.1
• Coordinates: 1339337..1339591 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KO461_RS06700 (KO461_06690)	1334479..1334865	-	387	WP_005540074.1	hypothetical protein	-
KO461_RS06705 (KO461_06695)	1334904..1335794	-	891	WP_005565406.1	WYL domain-containing transcriptional regulator	-
KO461_RS06710 (KO461_06700)	1336313..1337701	-	1389	WP_205764658.1	tRNA 5-hydroxyuridine modification protein YegQ	-
KO461_RS06715 (KO461_06705)	1337873..1338316	-	444	WP_005552694.1	YeeE/YedE thiosulfate transporter family protein	-
KO461_RS06720 (KO461_06710)	1338657..1338995	+	339	WP_005540087.1	cupin domain-containing protein	-
KO461_RS06725 (KO461_06715)	1339057..1339347	-	291	WP_005540089.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KO461_RS06730 (KO461_06720)	1339337..1339591	-	255	WP_005565410.1	stability protein StbD	Antitoxin
KO461_RS06745 (KO461_06735)	1340043..1340804	-	762	WP_005540094.1	DNA polymerase III subunit epsilon	-
KO461_RS06750 (KO461_06740)	1340872..1341339	+	468	WP_005565412.1	ribonuclease HI	-
KO461_RS06755 (KO461_06745)	1341427..1342758	-	1332	WP_205764657.1	3-phosphoshikimate 1-carboxyvinyltransferase	-
KO461_RS06760 (KO461_06750)	1342769..1343867	-	1099	Protein_1308	histidinol-phosphate transaminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11509.34 Da
• Isoelectric Point: 10.7396

>T205682 WP_005540089.1 NZ_CP076449:c1339347-1339057 [Aggregatibacter actinomycetemcomitans]
MTYKLTFDKRALKEWQKLGDTIRQQFKNKLAERLENPRVPGDKLRGYQNLYKIKLRAAGYRLVYEVNDNQIYILVLSVGK
RNRLDAYKNAEFRQAR

Nucleotide

• Length: 291 bp

>T205682 NZ_CP101835:324617-324985 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9294.53 Da
• Isoelectric Point: 3.9649

>AT205682 WP_005565410.1 NZ_CP076449:c1339591-1339337 [Aggregatibacter actinomycetemcomitans]
MAIHQILTQQAASITDLKRDPMGIAYASQDGAVAILNRNQPAFYCVTPALFEYFQNLVEDAELGRIAEERLATLDPIEVS
IDDL

Nucleotide

• Length: 255 bp

>AT205682 NZ_CP101835:324399-324620 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A142FYB7