Detailed information of TA system TA205678

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1417046..1417593
• Replicon: chromosome
• Accession: NZ_CP076443
• Organism: Gemella sp. zg-570

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KMP11_RS06895
• Protein ID: WP_215756396.1
• Coordinates: 1417321..1417593 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KMP11_RS06890
• Protein ID: WP_215756395.1
• Coordinates: 1417046..1417321 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KMP11_RS06860 (KMP11_06865)	1412363..1412584	-	222	WP_215756390.1	DUF4314 domain-containing protein	-
KMP11_RS06865 (KMP11_06870)	1412565..1412756	-	192	WP_163545661.1	hypothetical protein	-
KMP11_RS06870 (KMP11_06875)	1412819..1414258	-	1440	WP_215756391.1	DNA (cytosine-5-)-methyltransferase	-
KMP11_RS06875 (KMP11_06880)	1414251..1415492	-	1242	WP_215756392.1	site-specific DNA-methyltransferase	-
KMP11_RS06880 (KMP11_06885)	1415502..1416284	-	783	WP_215756393.1	S-adenosylmethionine synthetase N-terminal domain-containing protein	-
KMP11_RS06885 (KMP11_06890)	1416287..1416838	-	552	WP_216279812.1	terminase	-
KMP11_RS06890 (KMP11_06895)	1417046..1417321	+	276	WP_215756395.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KMP11_RS06895 (KMP11_06900)	1417321..1417593	+	273	WP_215756396.1	type II toxin-antitoxin system YafQ family toxin	Toxin
KMP11_RS06900 (KMP11_06905)	1417610..1417900	-	291	WP_252344692.1	HNH endonuclease signature motif containing protein	-
KMP11_RS06905 (KMP11_06910)	1418076..1418531	-	456	WP_215756398.1	DUF1492 domain-containing protein	-
KMP11_RS06910 (KMP11_06915)	1418577..1419920	-	1344	WP_216279813.1	DEAD/DEAH box helicase	-
KMP11_RS06915 (KMP11_06920)	1419901..1420182	-	282	WP_215756400.1	VRR-NUC domain-containing protein	-
KMP11_RS06920 (KMP11_06925)	1420305..1422551	-	2247	WP_216279814.1	phage/plasmid primase, P4 family	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1340976..1439644	98668

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-69)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10658.46 Da
• Isoelectric Point: 8.8102

>T205678 WP_215756396.1 NZ_CP076443:1417321-1417593 [Gemella sp. zg-570]
MYHIKYTNKFKKSYKLMKKRGYDLSLLEDVITKLSKGIPLEEKHRNHMLTGNFAGYHECHIKPDWLLIYLIENDILTLTM
IDTGSHSDLF

Nucleotide

• Length: 273 bp

>T205678 NZ_CP101831:1356555-1356857 [Lacticaseibacillus paracasei]
ATGTATAGTCTGGTTCCGACGCCTACATTTAAGCGCGATCTAAAACGACTCTCCAAGAAGCATTGGCCGATGGACGAACT
AAAGACGGCTGTTAATCTCCTAGCCGCTGGTACAAATGCTGAACTATTAAGCAAAAAGTATGCAGATCATGCCTTGTCCT
CAAGCAGCGAGTGGAAAGGATATCGTGAACTATATGTTGACGGCCCTCGTGGCGACTGGTTGCTAATCTATAAAATTGAG
CAGCAAGATCTTATTTTAACCCTAGTTAGAACCGGATCTCATCATAACCTTCTGGTTAAATAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10170.59 Da
• Isoelectric Point: 4.5881

>AT205678 WP_215756395.1 NZ_CP076443:1417046-1417321 [Gemella sp. zg-570]
MATSPTQIRIDSTVKEDANALFSRLGLDMSSAVNMFLRQCVLRGGLPFTVELPKYNQETLDAMEEARKISKDPNVPSYSS
VKDLFKALDEE

Nucleotide

• Length: 276 bp

>AT205678 NZ_CP101831:1356293-1356562 [Lacticaseibacillus paracasei]
ATGGCAGCCACAAAGAAGGAAACTCGCTTGAATATTCGTGTTGATCCTGAATTAAAAAGTGCTGCTCAAATCGTAGCAAA
TGATATGGGCATCGACTTGACCGCAGCTGTTACGATGTTCATGACGAAAATGGTGAAAGATCACGCCCTCCCGTTTACCC
CAACAAGTCTACCAGTTGAAACCTTACAGGCGCTGAAAGAAGCAAAGCACCCAGAGCTGCTCAAAAAATACAGCACGCCT
GATGACATGTGGAGAGACTTGAATGTATAG