Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1711821..1713563 Replicon chromosome
Accession NZ_CP076412
Organism Ralstonia wenshanensis strain 56D2

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag KOL96_RS07600 Protein ID WP_232039317.1
Coordinates 1711821..1712723 (+) Length 301 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag KOL96_RS07605 Protein ID WP_232039318.1
Coordinates 1712736..1713563 (+) Length 276 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOL96_RS07565 (KOL96_07525) 1707264..1707740 + 477 WP_232039312.1 nuclear transport factor 2 family protein -
KOL96_RS07570 (KOL96_07530) 1707789..1708127 - 339 WP_232039313.1 AraC family transcriptional regulator -
KOL96_RS07575 (KOL96_07535) 1708280..1708846 + 567 WP_232039314.1 TetR/AcrR family transcriptional regulator -
KOL96_RS07580 (KOL96_07540) 1709029..1709334 + 306 WP_232039315.1 hypothetical protein -
KOL96_RS07585 (KOL96_07545) 1709414..1710481 + 1068 WP_024979224.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
KOL96_RS07590 (KOL96_07550) 1710474..1711247 + 774 WP_232039316.1 SDR family oxidoreductase -
KOL96_RS07595 (KOL96_07555) 1711280..1711816 + 537 WP_024974097.1 cupin domain-containing protein -
KOL96_RS07600 (KOL96_07560) 1711821..1712723 + 903 WP_232039317.1 alpha/beta hydrolase Toxin
KOL96_RS07605 (KOL96_07565) 1712736..1713563 + 828 WP_232039318.1 IclR family transcriptional regulator Antitoxin
KOL96_RS07610 (KOL96_07570) 1713566..1714369 + 804 WP_232039319.1 SDR family oxidoreductase -
KOL96_RS07615 (KOL96_07575) 1714362..1716089 + 1728 WP_232039320.1 thiamine pyrophosphate-binding protein -
KOL96_RS07620 (KOL96_07580) 1716122..1716925 + 804 WP_232040251.1 aspartate dehydrogenase -
KOL96_RS07625 (KOL96_07585) 1716942..1718444 + 1503 WP_232039321.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-288)

Antitoxin

Transcription regulator IclR, N-terminal

(19-68)


Sequences

Toxin        


Download         Length: 301 a.a.        Molecular weight: 31590.88 Da        Isoelectric Point: 6.9009

>T205674 WP_232039317.1 NZ_CP076412:1711821-1712723 [Ralstonia wenshanensis]
MSAQAVMSSHPFRVADALAVLGAGFAERAVAINAHGDRIGYRQWGERGPVVVLLHGISSSAASWLPCAQVLSRNMRVLAW
DAPGYGNSTPLEQATPSAADYAVRLQAWLAALDVTPDVIVGHSLGALMASAYVAAAPAAMQPKCLLLLNPAQGYGQPGQE
DKSRAVQAQRLSTLDQLGIAGMAESRHAHLLRPNATDEERAWVRWNMKRLNDGGYRQAVAMLSGDDIGAYLRKRPASTPA
QVACGDVDGITPPQGCEALAKTFGLPFALVPAAGHASYIDAPDAVAGWIEHAVLSQSQNA

Download         Length: 903 bp

>T205674 NZ_CP101794:c138961-138518 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 276 a.a.        Molecular weight: 30616.44 Da        Isoelectric Point: 6.5031

>AT205674 WP_232039318.1 NZ_CP076412:1712736-1713563 [Ralstonia wenshanensis]
MSNDLISEDVQEKYIVPGLERGLRLLCEFSHKDRVLSAPELARRLKVPRSTVFRLLTTLEVMGFIERVDGGRDFRLGMAV
LRLGFEYLASLELTELGRPLLDRLRDEIHYPCNLVVRDGRSIVYVAKSVAPTPFTSSVNVGTRLPAHATVLGRVLLADLS
LAELRQLYPEPQLEVFSANTPRTVEALFEMVQRDREHGYVLQEGFFEANISTIAAPVLDRAGKVVAALGTTIPSPRIDAA
QLDLMIDKVRAAAGELSYLLDYRPAGGKVVNLFRE

Download         Length: 828 bp

>AT205674 NZ_CP101794:c139188-138958 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References