Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 957444..958048 Replicon chromosome
Accession NZ_CP076412
Organism Ralstonia wenshanensis strain 56D2

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KOL96_RS04165 Protein ID WP_232038728.1
Coordinates 957444..957743 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag KOL96_RS04170 Protein ID WP_232038729.1
Coordinates 957746..958048 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOL96_RS04140 (KOL96_04120) 953097..953531 - 435 WP_232038723.1 VOC family protein -
KOL96_RS04145 (KOL96_04125) 953774..954352 - 579 WP_232038724.1 GNAT family N-acetyltransferase -
KOL96_RS04150 (KOL96_04130) 954487..955029 + 543 WP_232038725.1 helix-turn-helix domain-containing protein -
KOL96_RS04155 (KOL96_04135) 955201..956037 + 837 WP_232038726.1 GntR family transcriptional regulator -
KOL96_RS04160 (KOL96_04140) 956138..957364 + 1227 WP_232038727.1 MFS transporter -
KOL96_RS04165 (KOL96_04145) 957444..957743 + 300 WP_232038728.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KOL96_RS04170 (KOL96_04150) 957746..958048 + 303 WP_232038729.1 putative addiction module antidote protein Antitoxin
KOL96_RS04175 (KOL96_04155) 958221..959525 + 1305 WP_232038730.1 MFS family transporter -
KOL96_RS04180 (KOL96_04160) 959715..960617 - 903 WP_232038731.1 type III effector protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-85)

Antitoxin

Uncharacterized protein HI1420

(8-97)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11253.96 Da        Isoelectric Point: 10.6580

>T205673 WP_232038728.1 NZ_CP076412:957444-957743 [Ralstonia wenshanensis]
MLTIRTTNAFDTWFSRLRDKTAQRRIQVRIDRLQLGHPGDVKAVRAGVSELRINHGPGYPVYFVQRGAVLIILLCGGDKS
TQEADIRRAIELSRHLDVE

Download         Length: 300 bp

>T205673 NZ_CP101794:c83925-83455 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10852.45 Da        Isoelectric Point: 6.2202

>AT205673 WP_232038729.1 NZ_CP076412:957746-958048 [Ralstonia wenshanensis]
MPNDKPVKTRPWDSAEHLKTEADMAAYLDACLEEAADDPAFITHALGVVARARGMTQLARDTGMTREGLYKALSEEGNPS
FATVLKVMRALGIRLHAVAV

Download         Length: 303 bp

>AT205673 NZ_CP101794:c84365-83922 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References