Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 4234122..4234705 Replicon chromosome
Accession NZ_CP076407
Organism Providencia rettgeri strain PreM15758

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KOL64_RS19290 Protein ID WP_282559865.1
Coordinates 4234391..4234705 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KOL64_RS19285 Protein ID WP_004265229.1
Coordinates 4234122..4234406 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOL64_RS19260 (KOL64_19270) 4229282..4230259 - 978 WP_004265237.1 6-phosphofructokinase -
KOL64_RS19265 (KOL64_19275) 4230666..4231610 - 945 WP_102140623.1 phosphatidate cytidylyltransferase -
KOL64_RS19270 (KOL64_19280) 4231586..4232248 - 663 WP_283656636.1 lysophospholipid acyltransferase family protein -
KOL64_RS19275 (KOL64_19285) 4232486..4233238 - 753 WP_004907010.1 M48 family metallopeptidase -
KOL64_RS19280 (KOL64_19290) 4233458..4234039 - 582 WP_094961882.1 HutD family protein -
KOL64_RS19285 (KOL64_19295) 4234122..4234406 - 285 WP_004265229.1 putative addiction module antidote protein Antitoxin
KOL64_RS19290 (KOL64_19300) 4234391..4234705 - 315 WP_282559865.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KOL64_RS19295 (KOL64_19305) 4235014..4235784 + 771 WP_215954251.1 hypothetical protein -
KOL64_RS19300 (KOL64_19310) 4235815..4236033 - 219 WP_112308381.1 ogr/Delta-like zinc finger family protein -
KOL64_RS19305 (KOL64_19315) 4236105..4237202 - 1098 WP_071548728.1 phage late control D family protein -
KOL64_RS19310 (KOL64_19320) 4237190..4237645 - 456 WP_283656637.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(3-91)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11773.79 Da        Isoelectric Point: 10.0723

>T205668 WP_282559865.1 NZ_CP076407:c4234705-4234391 [Providencia rettgeri]
MITVLTTECFDSWIKNLRDIRAKTKILMRIRRLKNGNYGDVQPIGDGFSELRVHEGQGYRVYLKQKNNVIVILLCGGTKA
TQQKDIHKAKLLFGEVEGELILN

Download         Length: 315 bp

>T205668 NZ_CP101790:c4696634-4696350 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10454.13 Da        Isoelectric Point: 4.5983

>AT205668 WP_004265229.1 NZ_CP076407:c4234406-4234122 [Providencia rettgeri]
MNTKLKEFDIAEYLNSEEEIQMYLNEILEEGDPSLVLAALGDIAKARNMSQLAKEVGMSREGLYKALSGQGNPTFMTIIK
IVNSLGLKLQFKSI

Download         Length: 285 bp

>AT205668 NZ_CP101790:c4696866-4696624 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References