Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 3967447..3968032 Replicon chromosome
Accession NZ_CP076407
Organism Providencia rettgeri strain PreM15758

Toxin (Protein)


Gene name relE Uniprot ID D4C3N9
Locus tag KOL64_RS17930 Protein ID WP_004905874.1
Coordinates 3967447..3967764 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4C3P0
Locus tag KOL64_RS17935 Protein ID WP_004905876.1
Coordinates 3967745..3968032 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOL64_RS17900 (KOL64_17925) 3963150..3963401 - 252 WP_140171816.1 DUF1471 domain-containing protein -
KOL64_RS17905 (KOL64_17930) 3963672..3964010 + 339 WP_140171817.1 GIY-YIG nuclease family protein -
KOL64_RS17910 (KOL64_17935) 3963983..3964486 - 504 WP_112308100.1 N-acetyltransferase -
KOL64_RS17915 (KOL64_17940) 3964480..3965004 - 525 WP_140171818.1 SCP2 domain-containing protein -
KOL64_RS17920 (KOL64_17945) 3965519..3966514 + 996 WP_140171819.1 peptidase U32 family protein -
KOL64_RS17925 (KOL64_17950) 3966532..3967437 + 906 WP_283656619.1 U32 family peptidase -
KOL64_RS17930 (KOL64_17955) 3967447..3967764 - 318 WP_004905874.1 type II toxin-antitoxin system YafQ family toxin Toxin
KOL64_RS17935 (KOL64_17960) 3967745..3968032 - 288 WP_004905876.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KOL64_RS17940 (KOL64_17965) 3968163..3969317 - 1155 WP_140171821.1 ABC transporter permease -
KOL64_RS17945 (KOL64_17970) 3969317..3970462 - 1146 WP_004905879.1 ABC transporter permease -
KOL64_RS17950 (KOL64_17975) 3970474..3971445 - 972 WP_140171822.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(14-105)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12205.96 Da        Isoelectric Point: 9.7799

>T205667 WP_004905874.1 NZ_CP076407:c3967764-3967447 [Providencia rettgeri]
MTQKPSNKRAKQPRQVAYTPTFKKSWERYNRAGRRDMNAAVLVMEILFSQKIIPKEYLDHELEGHEWQGARELHIGGDFL
LVYRLSDKGNLITFVDIGSHSELFG

Download         Length: 318 bp

>T205667 NZ_CP101790:c4600076-4599543 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGTATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10763.44 Da        Isoelectric Point: 5.8809

>AT205667 WP_004905876.1 NZ_CP076407:c3968032-3967745 [Providencia rettgeri]
MSTLLKTTDVRSRIDEQLKAEATSVLQDCGLTISAAIRLFLEQVVQEQRVPFEIKRKQPSLKTTLALKEAKAIEQHYDSI
NEMMVELSKVDSEAK

Download         Length: 288 bp

>AT205667 NZ_CP101790:c4600353-4600087 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4C3N9

Antitoxin

Source ID Structure
AlphaFold DB A0A345M0A6

References