Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2793776..2794311 Replicon chromosome
Accession NZ_CP076407
Organism Providencia rettgeri strain PreM15758

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag KOL64_RS12455 Protein ID WP_140170723.1
Coordinates 2794003..2794311 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag KOL64_RS12450 Protein ID WP_140170722.1
Coordinates 2793776..2794003 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOL64_RS12430 (KOL64_12435) 2789058..2789498 + 441 WP_110591516.1 flagellar export chaperone FlgN -
KOL64_RS12435 (KOL64_12440) 2789685..2790116 + 432 WP_140170720.1 hypothetical protein -
KOL64_RS12440 (KOL64_12445) 2790269..2792368 - 2100 WP_004255687.1 flagellar biosynthesis protein FlhA -
KOL64_RS12445 (KOL64_12450) 2792361..2793512 - 1152 WP_140170721.1 flagellar biosynthesis protein FlhB -
KOL64_RS12450 (KOL64_12455) 2793776..2794003 + 228 WP_140170722.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
KOL64_RS12455 (KOL64_12460) 2794003..2794311 + 309 WP_140170723.1 CcdB family protein Toxin
KOL64_RS12460 (KOL64_12465) 2794327..2794884 + 558 WP_140170724.1 hypothetical protein -
KOL64_RS22330 (KOL64_12470) 2794918..2795244 - 327 WP_282555854.1 helix-turn-helix transcriptional regulator -
KOL64_RS12470 (KOL64_12475) 2795331..2795969 - 639 WP_094961165.1 protein phosphatase CheZ -
KOL64_RS12475 (KOL64_12480) 2795994..2796386 - 393 WP_004255705.1 chemotaxis response regulator CheY -
KOL64_RS12480 (KOL64_12485) 2796428..2797495 - 1068 WP_140170725.1 chemotaxis response regulator protein-glutamate methylesterase -
KOL64_RS12485 (KOL64_12490) 2797495..2798331 - 837 WP_004255713.1 chemotaxis protein-glutamate O-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(5-75)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11770.87 Da        Isoelectric Point: 8.0469

>T205666 WP_140170723.1 NZ_CP076407:2794003-2794311 [Providencia rettgeri]
MQYRLYQNRDDAIKYPYLLDIQSNIIDLLNTRLVIPLFDSRLVKKPLPARLNPQLVINGQVFILMTHQMACVPHSLLGKE
IVDLSSQRDTIKHAIDLLIDGF

Download         Length: 309 bp

>T205666 NZ_CP101790:3996466-3996684 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8660.87 Da        Isoelectric Point: 8.9375

>AT205666 WP_140170722.1 NZ_CP076407:2793776-2794003 [Providencia rettgeri]
MNRTKKTVSVTVAPELYEQARRAKLNLSAILACALQAELKRLEAQKWKNDNAEGFNELNRINEEYGLLSDKYKDF

Download         Length: 228 bp

>AT205666 NZ_CP101790:3996065-3996439 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References