Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1697448..1698096 Replicon chromosome
Accession NZ_CP076407
Organism Providencia rettgeri strain PreM15758

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KOL64_RS07330 Protein ID WP_094961724.1
Coordinates 1697911..1698096 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KOL64_RS07325 Protein ID WP_094961723.1
Coordinates 1697448..1697861 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOL64_RS07300 (KOL64_07320) 1692763..1693899 - 1137 WP_180359534.1 M4 family metallopeptidase -
KOL64_RS07305 (KOL64_07325) 1694058..1694975 - 918 WP_140172324.1 oxygen-dependent coproporphyrinogen oxidase -
KOL64_RS07310 (KOL64_07330) 1695112..1695543 + 432 WP_109911483.1 GNAT family acetyltransferase -
KOL64_RS07315 (KOL64_07335) 1695635..1696240 + 606 WP_140172325.1 RpoE-regulated lipoprotein -
KOL64_RS07320 (KOL64_07340) 1696483..1697379 + 897 Protein_1428 Dyp-type peroxidase -
KOL64_RS07325 (KOL64_07345) 1697448..1697861 - 414 WP_094961723.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KOL64_RS07330 (KOL64_07350) 1697911..1698096 - 186 WP_094961724.1 type II toxin-antitoxin system HicA family toxin Toxin
KOL64_RS07335 (KOL64_07355) 1698419..1699441 + 1023 WP_140172326.1 sulfate ABC transporter substrate-binding protein -
KOL64_RS07340 (KOL64_07360) 1699441..1700271 + 831 WP_004264883.1 sulfate/thiosulfate ABC transporter permease CysT -
KOL64_RS07345 (KOL64_07365) 1700271..1701131 + 861 WP_200129238.1 sulfate/thiosulfate ABC transporter permease CysW -
KOL64_RS07350 (KOL64_07370) 1701134..1702228 + 1095 WP_283656742.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6992.20 Da        Isoelectric Point: 11.0146

>T205665 WP_094961724.1 NZ_CP076407:c1698096-1697911 [Providencia rettgeri]
VQSSELINILQKNGWKLERIKGSHHQFSHPHFSIVITVPHPQKDLKIGTLNHILKAAKLKH

Download         Length: 186 bp

>T205665 NZ_CP101790:c3873249-3872932 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15362.31 Da        Isoelectric Point: 4.6719

>AT205665 WP_094961723.1 NZ_CP076407:c1697861-1697448 [Providencia rettgeri]
MLYTAFIEIDNDGSASGWFPDIEGCTFAGSNIEEAYAEAKSAIDAHFELLSEKGFEIPLSKSQQTLLNPIQPEYAHGIWL
FVDVDMDKYDGRTERINITLPHRLLHRIDALVKVNPEYGSRSGFIAAAARKELKKTD

Download         Length: 414 bp

>AT205665 NZ_CP101790:c3872939-3872652 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References