Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 4234737..4235320 Replicon chromosome
Accession NZ_CP076406
Organism Providencia rettgeri strain PreM15793

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KOL65_RS19245 Protein ID WP_282559865.1
Coordinates 4235006..4235320 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KOL65_RS19240 Protein ID WP_004265229.1
Coordinates 4234737..4235021 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOL65_RS19215 (KOL65_19265) 4229897..4230874 - 978 WP_004265237.1 6-phosphofructokinase -
KOL65_RS19220 (KOL65_19270) 4231281..4232225 - 945 WP_102140623.1 phosphatidate cytidylyltransferase -
KOL65_RS19225 (KOL65_19275) 4232201..4232863 - 663 WP_283656636.1 lysophospholipid acyltransferase family protein -
KOL65_RS19230 (KOL65_19280) 4233101..4233853 - 753 WP_004907010.1 M48 family metallopeptidase -
KOL65_RS19235 (KOL65_19285) 4234073..4234654 - 582 WP_094961882.1 HutD family protein -
KOL65_RS19240 (KOL65_19290) 4234737..4235021 - 285 WP_004265229.1 putative addiction module antidote protein Antitoxin
KOL65_RS19245 (KOL65_19295) 4235006..4235320 - 315 WP_282559865.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KOL65_RS19250 (KOL65_19300) 4235629..4236399 + 771 WP_215954251.1 hypothetical protein -
KOL65_RS19255 (KOL65_19305) 4236430..4236648 - 219 WP_112308381.1 ogr/Delta-like zinc finger family protein -
KOL65_RS19260 (KOL65_19310) 4236720..4237817 - 1098 WP_071548728.1 phage late control D family protein -
KOL65_RS19265 (KOL65_19315) 4237805..4238260 - 456 WP_283656637.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4234737..4266466 31729


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(3-91)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11773.79 Da        Isoelectric Point: 10.0723

>T205663 WP_282559865.1 NZ_CP076406:c4235320-4235006 [Providencia rettgeri]
MITVLTTECFDSWIKNLRDIRAKTKILMRIRRLKNGNYGDVQPIGDGFSELRVHEGQGYRVYLKQKNNVIVILLCGGTKA
TQQKDIHKAKLLFGEVEGELILN

Download         Length: 315 bp

>T205663 NZ_CP101790:1955718-1955820 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10454.13 Da        Isoelectric Point: 4.5983

>AT205663 WP_004265229.1 NZ_CP076406:c4235021-4234737 [Providencia rettgeri]
MNTKLKEFDIAEYLNSEEEIQMYLNEILEEGDPSLVLAALGDIAKARNMSQLAKEVGMSREGLYKALSGQGNPTFMTIIK
IVNSLGLKLQFKSI

Download         Length: 285 bp

>AT205663 NZ_CP101790:c1955827-1955682 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References