Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 3967843..3968428 Replicon chromosome
Accession NZ_CP076406
Organism Providencia rettgeri strain PreM15793

Toxin (Protein)


Gene name relE Uniprot ID D4C3N9
Locus tag KOL65_RS17890 Protein ID WP_004905874.1
Coordinates 3967843..3968160 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4C3P0
Locus tag KOL65_RS17895 Protein ID WP_004905876.1
Coordinates 3968141..3968428 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOL65_RS17860 (KOL65_17920) 3963546..3963797 - 252 WP_140171816.1 DUF1471 domain-containing protein -
KOL65_RS17865 (KOL65_17925) 3964068..3964406 + 339 WP_140171817.1 GIY-YIG nuclease family protein -
KOL65_RS17870 (KOL65_17930) 3964379..3964882 - 504 WP_112308100.1 N-acetyltransferase -
KOL65_RS17875 (KOL65_17935) 3964876..3965400 - 525 WP_140171818.1 SCP2 domain-containing protein -
KOL65_RS17880 (KOL65_17940) 3965915..3966910 + 996 WP_140171819.1 peptidase U32 family protein -
KOL65_RS17885 (KOL65_17945) 3966928..3967833 + 906 WP_283656619.1 U32 family peptidase -
KOL65_RS17890 (KOL65_17950) 3967843..3968160 - 318 WP_004905874.1 type II toxin-antitoxin system YafQ family toxin Toxin
KOL65_RS17895 (KOL65_17955) 3968141..3968428 - 288 WP_004905876.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KOL65_RS17900 (KOL65_17960) 3968559..3969713 - 1155 WP_140171821.1 ABC transporter permease -
KOL65_RS17905 (KOL65_17965) 3969713..3970858 - 1146 WP_004905879.1 ABC transporter permease -
KOL65_RS17910 (KOL65_17970) 3970870..3971841 - 972 WP_140171822.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(14-105)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12205.96 Da        Isoelectric Point: 9.7799

>T205662 WP_004905874.1 NZ_CP076406:c3968160-3967843 [Providencia rettgeri]
MTQKPSNKRAKQPRQVAYTPTFKKSWERYNRAGRRDMNAAVLVMEILFSQKIIPKEYLDHELEGHEWQGARELHIGGDFL
LVYRLSDKGNLITFVDIGSHSELFG

Download         Length: 318 bp

>T205662 NZ_CP101790:794514-794924 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10763.44 Da        Isoelectric Point: 5.8809

>AT205662 WP_004905876.1 NZ_CP076406:c3968428-3968141 [Providencia rettgeri]
MSTLLKTTDVRSRIDEQLKAEATSVLQDCGLTISAAIRLFLEQVVQEQRVPFEIKRKQPSLKTTLALKEAKAIEQHYDSI
NEMMVELSKVDSEAK

Download         Length: 288 bp

>AT205662 NZ_CP101790:794267-794533 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4C3N9

Antitoxin

Source ID Structure
AlphaFold DB A0A345M0A6

References