Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2794321..2794856 Replicon chromosome
Accession NZ_CP076406
Organism Providencia rettgeri strain PreM15793

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag KOL65_RS12415 Protein ID WP_140170723.1
Coordinates 2794548..2794856 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag KOL65_RS12410 Protein ID WP_140170722.1
Coordinates 2794321..2794548 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOL65_RS12390 (KOL65_12435) 2789603..2790043 + 441 WP_110591516.1 flagellar export chaperone FlgN -
KOL65_RS12395 (KOL65_12440) 2790230..2790661 + 432 WP_140170720.1 hypothetical protein -
KOL65_RS12400 (KOL65_12445) 2790814..2792913 - 2100 WP_004255687.1 flagellar biosynthesis protein FlhA -
KOL65_RS12405 (KOL65_12450) 2792906..2794057 - 1152 WP_140170721.1 flagellar biosynthesis protein FlhB -
KOL65_RS12410 (KOL65_12455) 2794321..2794548 + 228 WP_140170722.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
KOL65_RS12415 (KOL65_12460) 2794548..2794856 + 309 WP_140170723.1 CcdB family protein Toxin
KOL65_RS12420 (KOL65_12465) 2794872..2795429 + 558 WP_140170724.1 hypothetical protein -
KOL65_RS12425 (KOL65_12470) 2795463..2795789 - 327 WP_282555854.1 helix-turn-helix transcriptional regulator -
KOL65_RS12430 (KOL65_12475) 2795876..2796514 - 639 WP_094961165.1 protein phosphatase CheZ -
KOL65_RS12435 (KOL65_12480) 2796539..2796931 - 393 WP_004255705.1 chemotaxis response regulator CheY -
KOL65_RS12440 (KOL65_12485) 2796973..2798040 - 1068 WP_140170725.1 chemotaxis response regulator protein-glutamate methylesterase -
KOL65_RS12445 (KOL65_12490) 2798040..2798876 - 837 WP_004255713.1 chemotaxis protein-glutamate O-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(5-75)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11770.87 Da        Isoelectric Point: 8.0469

>T205661 WP_140170723.1 NZ_CP076406:2794548-2794856 [Providencia rettgeri]
MQYRLYQNRDDAIKYPYLLDIQSNIIDLLNTRLVIPLFDSRLVKKPLPARLNPQLVINGQVFILMTHQMACVPHSLLGKE
IVDLSSQRDTIKHAIDLLIDGF

Download         Length: 309 bp

>T205661 NZ_CP101790:351033-351380 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATTCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGAGCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8660.87 Da        Isoelectric Point: 8.9375

>AT205661 WP_140170722.1 NZ_CP076406:2794321-2794548 [Providencia rettgeri]
MNRTKKTVSVTVAPELYEQARRAKLNLSAILACALQAELKRLEAQKWKNDNAEGFNELNRINEEYGLLSDKYKDF

Download         Length: 228 bp

>AT205661 NZ_CP101790:351380-351679 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References