Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1697310..1697958 Replicon chromosome
Accession NZ_CP076406
Organism Providencia rettgeri strain PreM15793

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KOL65_RS07300 Protein ID WP_094961724.1
Coordinates 1697773..1697958 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KOL65_RS07295 Protein ID WP_094961723.1
Coordinates 1697310..1697723 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOL65_RS07270 (KOL65_07320) 1692625..1693761 - 1137 WP_180359534.1 M4 family metallopeptidase -
KOL65_RS07275 (KOL65_07325) 1693920..1694837 - 918 WP_140172324.1 oxygen-dependent coproporphyrinogen oxidase -
KOL65_RS07280 (KOL65_07330) 1694974..1695405 + 432 WP_109911483.1 GNAT family acetyltransferase -
KOL65_RS07285 (KOL65_07335) 1695497..1696102 + 606 WP_140172325.1 RpoE-regulated lipoprotein -
KOL65_RS07290 (KOL65_07340) 1696345..1697241 + 897 Protein_1425 Dyp-type peroxidase -
KOL65_RS07295 (KOL65_07345) 1697310..1697723 - 414 WP_094961723.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KOL65_RS07300 (KOL65_07350) 1697773..1697958 - 186 WP_094961724.1 type II toxin-antitoxin system HicA family toxin Toxin
KOL65_RS07305 (KOL65_07355) 1698281..1699303 + 1023 WP_140172326.1 sulfate ABC transporter substrate-binding protein -
KOL65_RS07310 (KOL65_07360) 1699303..1700133 + 831 WP_004264883.1 sulfate/thiosulfate ABC transporter permease CysT -
KOL65_RS07315 (KOL65_07365) 1700133..1700993 + 861 WP_200129238.1 sulfate/thiosulfate ABC transporter permease CysW -
KOL65_RS07320 (KOL65_07370) 1700996..1702090 + 1095 WP_283656742.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6992.20 Da        Isoelectric Point: 11.0146

>T205660 WP_094961724.1 NZ_CP076406:c1697958-1697773 [Providencia rettgeri]
VQSSELINILQKNGWKLERIKGSHHQFSHPHFSIVITVPHPQKDLKIGTLNHILKAAKLKH

Download         Length: 186 bp

>T205660 NZ_CP101790:325064-325432 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15362.31 Da        Isoelectric Point: 4.6719

>AT205660 WP_094961723.1 NZ_CP076406:c1697723-1697310 [Providencia rettgeri]
MLYTAFIEIDNDGSASGWFPDIEGCTFAGSNIEEAYAEAKSAIDAHFELLSEKGFEIPLSKSQQTLLNPIQPEYAHGIWL
FVDVDMDKYDGRTERINITLPHRLLHRIDALVKVNPEYGSRSGFIAAAARKELKKTD

Download         Length: 414 bp

>AT205660 NZ_CP101790:324846-325067 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References