Detailed information of TA system TA205658

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/COG3657-dnstrm_HI1420
• Location: 4235356..4235939
• Replicon: chromosome
• Accession: NZ_CP076405
• Organism: Providencia rettgeri strain PreM15628

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: KOF27_RS19270
• Protein ID: WP_282559865.1
• Coordinates: 4235625..4235939 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KOF27_RS19265
• Protein ID: WP_004265229.1
• Coordinates: 4235356..4235640 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KOF27_RS19240 (KOF27_19285)	4230516..4231493	-	978	WP_004265237.1	6-phosphofructokinase	-
KOF27_RS19245 (KOF27_19290)	4231900..4232844	-	945	WP_102140623.1	phosphatidate cytidylyltransferase	-
KOF27_RS19250 (KOF27_19295)	4232820..4233482	-	663	WP_283656636.1	lysophospholipid acyltransferase family protein	-
KOF27_RS19255 (KOF27_19300)	4233720..4234472	-	753	WP_004907010.1	M48 family metallopeptidase	-
KOF27_RS19260 (KOF27_19305)	4234692..4235273	-	582	WP_094961882.1	HutD family protein	-
KOF27_RS19265 (KOF27_19310)	4235356..4235640	-	285	WP_004265229.1	putative addiction module antidote protein	Antitoxin
KOF27_RS19270 (KOF27_19315)	4235625..4235939	-	315	WP_282559865.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KOF27_RS19275 (KOF27_19320)	4236248..4237018	+	771	WP_215954251.1	hypothetical protein	-
KOF27_RS19280 (KOF27_19325)	4237049..4237267	-	219	WP_112308381.1	ogr/Delta-like zinc finger family protein	-
KOF27_RS19285 (KOF27_19330)	4237339..4238436	-	1098	WP_071548728.1	phage late control D family protein	-
KOF27_RS19290 (KOF27_19335)	4238424..4238879	-	456	WP_283656637.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4235356..4267085	31729

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-95)

Antitoxin

• Uncharacterized protein HI1420 (3-91)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11773.79 Da
• Isoelectric Point: 10.0723

>T205658 WP_282559865.1 NZ_CP076405:c4235939-4235625 [Providencia rettgeri]
MITVLTTECFDSWIKNLRDIRAKTKILMRIRRLKNGNYGDVQPIGDGFSELRVHEGQGYRVYLKQKNNVIVILLCGGTKA
TQQKDIHKAKLLFGEVEGELILN

Nucleotide

• Length: 315 bp

>T205658 NZ_CP101787:c8087-7773 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10454.13 Da
• Isoelectric Point: 4.5983

>AT205658 WP_004265229.1 NZ_CP076405:c4235640-4235356 [Providencia rettgeri]
MNTKLKEFDIAEYLNSEEEIQMYLNEILEEGDPSLVLAALGDIAKARNMSQLAKEVGMSREGLYKALSGQGNPTFMTIIK
IVNSLGLKLQFKSI

Nucleotide

• Length: 285 bp

>AT205658 NZ_CP101787:c8353-8075 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA