Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 4235356..4235939 Replicon chromosome
Accession NZ_CP076405
Organism Providencia rettgeri strain PreM15628

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KOF27_RS19270 Protein ID WP_282559865.1
Coordinates 4235625..4235939 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KOF27_RS19265 Protein ID WP_004265229.1
Coordinates 4235356..4235640 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOF27_RS19240 (KOF27_19285) 4230516..4231493 - 978 WP_004265237.1 6-phosphofructokinase -
KOF27_RS19245 (KOF27_19290) 4231900..4232844 - 945 WP_102140623.1 phosphatidate cytidylyltransferase -
KOF27_RS19250 (KOF27_19295) 4232820..4233482 - 663 WP_283656636.1 lysophospholipid acyltransferase family protein -
KOF27_RS19255 (KOF27_19300) 4233720..4234472 - 753 WP_004907010.1 M48 family metallopeptidase -
KOF27_RS19260 (KOF27_19305) 4234692..4235273 - 582 WP_094961882.1 HutD family protein -
KOF27_RS19265 (KOF27_19310) 4235356..4235640 - 285 WP_004265229.1 putative addiction module antidote protein Antitoxin
KOF27_RS19270 (KOF27_19315) 4235625..4235939 - 315 WP_282559865.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KOF27_RS19275 (KOF27_19320) 4236248..4237018 + 771 WP_215954251.1 hypothetical protein -
KOF27_RS19280 (KOF27_19325) 4237049..4237267 - 219 WP_112308381.1 ogr/Delta-like zinc finger family protein -
KOF27_RS19285 (KOF27_19330) 4237339..4238436 - 1098 WP_071548728.1 phage late control D family protein -
KOF27_RS19290 (KOF27_19335) 4238424..4238879 - 456 WP_283656637.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4235356..4267085 31729


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(3-91)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11773.79 Da        Isoelectric Point: 10.0723

>T205658 WP_282559865.1 NZ_CP076405:c4235939-4235625 [Providencia rettgeri]
MITVLTTECFDSWIKNLRDIRAKTKILMRIRRLKNGNYGDVQPIGDGFSELRVHEGQGYRVYLKQKNNVIVILLCGGTKA
TQQKDIHKAKLLFGEVEGELILN

Download         Length: 315 bp

>T205658 NZ_CP101787:c8087-7773 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10454.13 Da        Isoelectric Point: 4.5983

>AT205658 WP_004265229.1 NZ_CP076405:c4235640-4235356 [Providencia rettgeri]
MNTKLKEFDIAEYLNSEEEIQMYLNEILEEGDPSLVLAALGDIAKARNMSQLAKEVGMSREGLYKALSGQGNPTFMTIIK
IVNSLGLKLQFKSI

Download         Length: 285 bp

>AT205658 NZ_CP101787:c8353-8075 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References