Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 3967841..3968426 Replicon chromosome
Accession NZ_CP076405
Organism Providencia rettgeri strain PreM15628

Toxin (Protein)


Gene name relE Uniprot ID D4C3N9
Locus tag KOF27_RS17910 Protein ID WP_004905874.1
Coordinates 3967841..3968158 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4C3P0
Locus tag KOF27_RS17915 Protein ID WP_004905876.1
Coordinates 3968139..3968426 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOF27_RS17880 (KOF27_17940) 3963544..3963795 - 252 WP_140171816.1 DUF1471 domain-containing protein -
KOF27_RS17885 (KOF27_17945) 3964066..3964404 + 339 WP_140171817.1 GIY-YIG nuclease family protein -
KOF27_RS17890 (KOF27_17950) 3964377..3964880 - 504 WP_112308100.1 N-acetyltransferase -
KOF27_RS17895 (KOF27_17955) 3964874..3965398 - 525 WP_140171818.1 SCP2 domain-containing protein -
KOF27_RS17900 (KOF27_17960) 3965913..3966908 + 996 WP_140171819.1 peptidase U32 family protein -
KOF27_RS17905 (KOF27_17965) 3966926..3967831 + 906 WP_283656619.1 U32 family peptidase -
KOF27_RS17910 (KOF27_17970) 3967841..3968158 - 318 WP_004905874.1 type II toxin-antitoxin system YafQ family toxin Toxin
KOF27_RS17915 (KOF27_17975) 3968139..3968426 - 288 WP_004905876.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KOF27_RS17920 (KOF27_17980) 3968557..3969711 - 1155 WP_140171821.1 ABC transporter permease -
KOF27_RS17925 (KOF27_17985) 3969711..3970856 - 1146 WP_004905879.1 ABC transporter permease -
KOF27_RS17930 (KOF27_17990) 3970868..3971839 - 972 WP_140171822.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(14-105)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12205.96 Da        Isoelectric Point: 9.7799

>T205657 WP_004905874.1 NZ_CP076405:c3968158-3967841 [Providencia rettgeri]
MTQKPSNKRAKQPRQVAYTPTFKKSWERYNRAGRRDMNAAVLVMEILFSQKIIPKEYLDHELEGHEWQGARELHIGGDFL
LVYRLSDKGNLITFVDIGSHSELFG

Download         Length: 318 bp

>T205657 NZ_CP101786:c108925-108482 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10763.44 Da        Isoelectric Point: 5.8809

>AT205657 WP_004905876.1 NZ_CP076405:c3968426-3968139 [Providencia rettgeri]
MSTLLKTTDVRSRIDEQLKAEATSVLQDCGLTISAAIRLFLEQVVQEQRVPFEIKRKQPSLKTTLALKEAKAIEQHYDSI
NEMMVELSKVDSEAK

Download         Length: 288 bp

>AT205657 NZ_CP101786:c109152-108922 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4C3N9

Antitoxin

Source ID Structure
AlphaFold DB A0A345M0A6

References