Detailed information of TA system TA205655

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1697179..1697827
• Replicon: chromosome
• Accession: NZ_CP076405
• Organism: Providencia rettgeri strain PreM15628

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KOF27_RS07315
• Protein ID: WP_094961724.1
• Coordinates: 1697642..1697827 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KOF27_RS07310
• Protein ID: WP_094961723.1
• Coordinates: 1697179..1697592 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KOF27_RS07285 (KOF27_07330)	1692494..1693630	-	1137	WP_180359534.1	M4 family metallopeptidase	-
KOF27_RS07290 (KOF27_07335)	1693789..1694706	-	918	WP_140172324.1	oxygen-dependent coproporphyrinogen oxidase	-
KOF27_RS07295 (KOF27_07340)	1694843..1695274	+	432	WP_109911483.1	GNAT family acetyltransferase	-
KOF27_RS07300 (KOF27_07345)	1695366..1695971	+	606	WP_140172325.1	RpoE-regulated lipoprotein	-
KOF27_RS07305 (KOF27_07350)	1696214..1697110	+	897	Protein_1428	Dyp-type peroxidase	-
KOF27_RS07310 (KOF27_07355)	1697179..1697592	-	414	WP_094961723.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KOF27_RS07315 (KOF27_07360)	1697642..1697827	-	186	WP_094961724.1	type II toxin-antitoxin system HicA family toxin	Toxin
KOF27_RS07320 (KOF27_07365)	1698150..1699172	+	1023	WP_140172326.1	sulfate ABC transporter substrate-binding protein	-
KOF27_RS07325 (KOF27_07370)	1699172..1700002	+	831	WP_004264883.1	sulfate/thiosulfate ABC transporter permease CysT	-
KOF27_RS07330 (KOF27_07375)	1700002..1700862	+	861	WP_200129238.1	sulfate/thiosulfate ABC transporter permease CysW	-
KOF27_RS07335 (KOF27_07380)	1700865..1701959	+	1095	WP_283656742.1	sulfate/thiosulfate ABC transporter ATP-binding protein CysA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6992.20 Da
• Isoelectric Point: 11.0146

>T205655 WP_094961724.1 NZ_CP076405:c1697827-1697642 [Providencia rettgeri]
VQSSELINILQKNGWKLERIKGSHHQFSHPHFSIVITVPHPQKDLKIGTLNHILKAAKLKH

Nucleotide

• Length: 186 bp

>T205655 NZ_CP101786:29854-30165 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15362.31 Da
• Isoelectric Point: 4.6719

>AT205655 WP_094961723.1 NZ_CP076405:c1697592-1697179 [Providencia rettgeri]
MLYTAFIEIDNDGSASGWFPDIEGCTFAGSNIEEAYAEAKSAIDAHFELLSEKGFEIPLSKSQQTLLNPIQPEYAHGIWL
FVDVDMDKYDGRTERINITLPHRLLHRIDALVKVNPEYGSRSGFIAAAARKELKKTD

Nucleotide

• Length: 414 bp

>AT205655 NZ_CP101786:30162-30581 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA