Detailed information of TA system TA205649

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4480909..4481723
• Replicon: chromosome
• Accession: NZ_CP076404
• Organism: Escherichia coli strain K-12 substr. AB1157

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: KJY95_RS21685
• Protein ID: WP_001054376.1
• Coordinates: 4481466..4481723 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: KJY95_RS21680
• Protein ID: WP_001309181.1
• Coordinates: 4480909..4481454 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJY95_RS21650 (4476600)	4476600..4477913	-	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-
KJY95_RS21655 (4477925)	4477925..4478203	-	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
KJY95_RS21660 (4478200)	4478200..4479321	-	1122	WP_000010829.1	M42 family metallopeptidase	-
KJY95_RS21665 (4479566)	4479566..4479682	-	117	Protein_4217	VOC family protein	-
KJY95_RS21670 (4479720)	4479720..4479938	-	219	Protein_4218	hypothetical protein	-
KJY95_RS21675 (4480107)	4480107..4480853	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
KJY95_RS21680 (4480909)	4480909..4481454	-	546	WP_001309181.1	N-acetyltransferase	Antitoxin
KJY95_RS21685 (4481466)	4481466..4481723	-	258	WP_001054376.1	YjhX family toxin	Toxin
KJY95_RS21690 (4482214)	4482214..4482345	-	132	WP_001309182.1	hypothetical protein	-
KJY95_RS21695 (4482461)	4482461..4483701	+	1241	Protein_4223	helicase YjhR	-
KJY95_RS21700 (4483969)	4483969..4484174	-	206	Protein_4224	HNH endonuclease	-
KJY95_RS21705 (4484284)	4484284..4485264	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
KJY95_RS21710 (4485329)	4485329..4486435	-	1107	WP_001309184.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T205649 WP_001054376.1 NZ_CP076404:c4481723-4481466 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T205649 NZ_CP101784:c4772509-4771976 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT205649 WP_001309181.1 NZ_CP076404:c4481454-4480909 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT205649 NZ_CP101784:c4772786-4772520 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8