Detailed information of TA system TA020563

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1591369..1592055
• Replicon: chromosome
• Accession: NC_002946
• Organism: Neisseria gonorrhoeae FA 1090

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q5F6D1
• Locus tag: NGO_RS08085
• Protein ID: WP_003689143.1
• Coordinates: 1591873..1592055 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q5F6D2
• Locus tag: NGO_RS08080
• Protein ID: WP_003691454.1
• Coordinates: 1591369..1591770 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NGO_RS08035	1586845..1587060	-	216	WP_003691538.1	hypothetical protein	-
NGO_RS08040	1587112..1587603	-	492	WP_004464807.1	siphovirus Gp157 family protein	-
NGO_RS08045	1587600..1587782	-	183	WP_003691535.1	hypothetical protein	-
NGO_RS08050	1587922..1588608	-	687	WP_030003517.1	hypothetical protein	-
NGO_RS11145	1588677..1588838	-	162	WP_003693867.1	hypothetical protein	-
NGO_RS08055	1588835..1589110	-	276	WP_003694990.1	hypothetical protein	-
NGO_RS08060	1589263..1589595	-	333	WP_003696914.1	hypothetical protein	-
NGO_RS08065	1589736..1589936	-	201	WP_003695499.1	hypothetical protein	-
NGO_RS08070	1590177..1590593	-	417	WP_003693479.1	hypothetical protein	-
NGO_RS08075	1590602..1591186	-	585	WP_003693477.1	SocA family protein	-
NGO_RS08080	1591369..1591770	-	402	WP_003691454.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
NGO_RS08085	1591873..1592055	-	183	WP_003689143.1	type II toxin-antitoxin system HicA family toxin	Toxin
NGO_RS08090	1592225..1593043	-	819	WP_003705996.1	DUF3037 domain-containing protein	-
NGO_RS08095	1593316..1594071	-	756	WP_003693472.1	LexA family transcriptional regulator	-
NGO_RS08100	1594208..1594393	+	186	WP_002238713.1	Cro/Cl family transcriptional regulator	-
NGO_RS11150	1594482..1594637	+	156	WP_003689578.1	hypothetical protein	-
NGO_RS08105	1594614..1594802	-	189	WP_010951308.1	hypothetical protein	-
NGO_RS08110	1594975..1595202	+	228	WP_003691442.1	helix-turn-helix domain-containing protein	-
NGO_RS08115	1595199..1596241	+	1043	Protein_1602	helix-turn-helix domain-containing protein	-
NGO_RS08120	1596257..1597036	+	780	WP_025455898.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1575855..1609652	33797

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.77 Da
• Isoelectric Point: 10.7235

>T20563 WP_003689143.1 NC_002946:c1592055-1591873 [Neisseria gonorrhoeae FA 1090]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK

Nucleotide

• Length: 183 bp

>T20563 NC_002946:c1592055-1591873 [Neisseria gonorrhoeae FA 1090]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14634.43 Da
• Isoelectric Point: 4.5457

>AT20563 WP_003691454.1 NC_002946:c1591770-1591369 [Neisseria gonorrhoeae FA 1090]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA

Nucleotide

• Length: 402 bp

>AT20563 NC_002946:c1591770-1591369 [Neisseria gonorrhoeae FA 1090]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTTACCATGAATCAGGCAT
AG

Structures

Toxin

• AlphaFold DB: Q5F6D1

Antitoxin

• AlphaFold DB: Q5F6D2