Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1467919..1468557 Replicon chromosome
Accession NZ_CP076404
Organism Escherichia coli strain K-12 substr. AB1157

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag KJY95_RS07150 Protein ID WP_000813794.1
Coordinates 1467919..1468095 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KJY95_RS07155 Protein ID WP_001270286.1
Coordinates 1468141..1468557 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJY95_RS07130 (1463538) 1463538..1464752 - 1215 WP_001326689.1 BenE family transporter YdcO -
KJY95_RS07135 (1464805) 1464805..1465341 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
KJY95_RS07140 (1465414) 1465414..1467375 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
KJY95_RS07145 (1467467) 1467467..1467697 - 231 WP_000494244.1 YncJ family protein -
KJY95_RS07150 (1467919) 1467919..1468095 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
KJY95_RS07155 (1468141) 1468141..1468557 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
KJY95_RS07160 (1468636) 1468636..1470042 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
KJY95_RS07165 (1470287) 1470287..1471432 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
KJY95_RS07170 (1471450) 1471450..1472463 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
KJY95_RS07175 (1472464) 1472464..1473405 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T205628 WP_000813794.1 NZ_CP076404:1467919-1468095 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T205628 NZ_CP101776:c3337002-3336826 [Klebsiella pneumoniae]
GTGAAGCAAAGCGAGTTGAGGCGTTGGCTTGCAGCTCAAGGGGCAGAATTTAAAGATGGTACTAACCACTTGAAAATCTA
TCTCAACGGCAAGCAAACGGTAATGCCGAGACATCCGGGGAAGGAAATACCGGAACCGCTGAGGAAGGCAATTCTTAAGC
AACTCGGTATCAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT205628 WP_001270286.1 NZ_CP076404:1468141-1468557 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT205628 NZ_CP101776:c3336778-3336371 [Klebsiella pneumoniae]
ATGCGATACCCGGTAATTTTTGAGCATGACGAAACCGGCTGGGCGGTATTCTTTCCGGATATCCCAGAGGCAATGACGGG
AGGAGAGACCAGGGAGGAAGCGTTAGAAATGGCGCAAGATGCCCTGGTGACGGCGTTTGATTTTTACTTTGACGACCGCC
GGGAGATTCCCGCTCCATCAGCAGAAGGTGATGCGTTTGTTGAGGTTCCGGCCAGCGTGGCAGCTAAAGTATTGCTGTTA
AACCGTCTGGTCAGCACCAACACCAGCAATGCTGATCTCGCCCGCTTGATTAACACGCGCCCACAGGAAGTGCAGCGCAT
CGTGTCTCTTGGTCACAGTACCAAAATCGATACGATCCAAAAAGCGCTATCAGCGTTGGGGCAAAAGATGGAAATTGTCG
TCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References