Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 887536..888191 Replicon chromosome
Accession NC_002946
Organism Neisseria gonorrhoeae FA 1090

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NGO_RS04480 Protein ID WP_003691083.1
Coordinates 887536..887955 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NGO_RS04485 Protein ID WP_003688410.1
Coordinates 887955..888191 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGO_RS04460 882770..884311 - 1542 WP_164920401.1 multidrug efflux MFS transporter -
NGO_RS04465 884459..885238 + 780 WP_003702609.1 (Fe-S)-binding protein -
NGO_RS04470 885235..885936 + 702 WP_003688414.1 lactate utilization protein C -
NGO_RS04475 885933..887387 + 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
NGO_RS04480 887536..887955 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NGO_RS04485 887955..888191 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NGO_RS04490 888397..889218 - 822 WP_003706481.1 IS3 family transposase -
NGO_RS04495 889223..889651 - 429 WP_010360042.1 helix-turn-helix domain-containing protein -
NGO_RS04500 889863..890249 + 387 Protein_896 IS110 family transposase -
NGO_RS04505 890632..891522 - 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
NGO_RS04510 891533..892699 - 1167 WP_003701280.1 ADP-forming succinate--CoA ligase subunit beta -
NGO_RS04515 892771..893058 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 889842..890315 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T20562 WP_003691083.1 NC_002946:c887955-887536 [Neisseria gonorrhoeae FA 1090]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T20562 NC_002946:c887955-887536 [Neisseria gonorrhoeae FA 1090]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT20562 WP_003688410.1 NC_002946:c888191-887955 [Neisseria gonorrhoeae FA 1090]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT20562 NC_002946:c888191-887955 [Neisseria gonorrhoeae FA 1090]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References