Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4268962..4269512 Replicon chromosome
Accession NZ_CP076386
Organism Dickeya dadantii strain S3-1

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag KNV89_RS18685 Protein ID WP_027711206.1
Coordinates 4269204..4269512 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag KNV89_RS18680 Protein ID WP_216282501.1
Coordinates 4268962..4269201 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KNV89_RS18655 (KNV89_18655) 4265156..4265517 + 362 Protein_3643 transposase -
KNV89_RS18660 (KNV89_18660) 4265895..4266335 + 441 WP_216282497.1 hypothetical protein -
KNV89_RS18665 (KNV89_18665) 4266564..4266941 + 378 WP_216282498.1 hypothetical protein -
KNV89_RS18670 (KNV89_18670) 4267361..4267546 - 186 Protein_3646 transposase -
KNV89_RS18675 (KNV89_18675) 4267645..4268568 + 924 WP_216282500.1 hypothetical protein -
KNV89_RS18680 (KNV89_18680) 4268962..4269201 + 240 WP_216282501.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
KNV89_RS18685 (KNV89_18685) 4269204..4269512 + 309 WP_027711206.1 CcdB family protein Toxin
KNV89_RS18690 (KNV89_18690) 4269889..4270686 + 798 WP_216282502.1 DUF2285 domain-containing protein -
KNV89_RS18695 (KNV89_18695) 4270770..4271066 + 297 WP_171852246.1 helix-turn-helix domain-containing protein -
KNV89_RS18700 (KNV89_18700) 4271093..4271905 + 813 WP_216282503.1 replication initiator protein A -
KNV89_RS18705 (KNV89_18705) 4272216..4272761 + 546 WP_216282504.1 S26 family signal peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vgrG1 / hcp 4258929..4331205 72276


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11697.53 Da        Isoelectric Point: 5.6557

>T205606 WP_027711206.1 NZ_CP076386:4269204-4269512 [Dickeya dadantii]
MQYMVYRNNDNSRAYPYLLDVQSDIIGELHTRLVIPLFPEEKVNASVVKRLTPVLPVEGRDYLVMTHEMASVRLSQLGPQ
VMDAQPYRQSIKAALDFLLDGF

Download         Length: 309 bp

>T205606 NZ_CP101770:883653-884060 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8931.02 Da        Isoelectric Point: 6.4674

>AT205606 WP_216282501.1 NZ_CP076386:4268962-4269201 [Dickeya dadantii]
MPATSVRHKKTVSVTLEPALLQQAREAGINLSATLAEALKREIRASEAEQWQRENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT205606 NZ_CP101770:883406-883672 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References