Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3982123..3982676 Replicon chromosome
Accession NZ_CP076386
Organism Dickeya dadantii strain S3-1

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag KNV89_RS17520 Protein ID WP_216282326.1
Coordinates 3982362..3982676 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag KNV89_RS17515 Protein ID WP_216282325.1
Coordinates 3982123..3982359 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KNV89_RS17495 (KNV89_17495) 3977647..3978531 - 885 WP_216282322.1 hypothetical protein -
KNV89_RS17500 (KNV89_17500) 3978907..3979755 + 849 WP_216282323.1 DNA/RNA non-specific endonuclease -
KNV89_RS22305 3979868..3980010 + 143 Protein_3411 integrase -
KNV89_RS22310 3980191..3980379 + 189 Protein_3412 transposase -
KNV89_RS17510 (KNV89_17510) 3980851..3981795 + 945 WP_216282324.1 zincin-like metallopeptidase domain-containing protein -
KNV89_RS17515 (KNV89_17515) 3982123..3982359 + 237 WP_216282325.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
KNV89_RS17520 (KNV89_17520) 3982362..3982676 + 315 WP_216282326.1 CcdB family protein Toxin
KNV89_RS22315 3982710..3982844 - 135 Protein_3416 mobilization protein mobC -
KNV89_RS17525 (KNV89_17525) 3983083..3984525 + 1443 WP_216282327.1 IS1182 family transposase -
KNV89_RS17530 (KNV89_17530) 3984908..3985972 + 1065 WP_216282328.1 hypothetical protein -
KNV89_RS17535 (KNV89_17535) 3986038..3986157 - 120 Protein_3419 IS481 family transposase -
KNV89_RS17540 (KNV89_17540) 3986197..3986340 - 144 Protein_3420 IS3 family transposase -
KNV89_RS17545 (KNV89_17545) 3986422..3986538 + 117 Protein_3421 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - hcp / vgrG1 3972575..4030463 57888


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11473.41 Da        Isoelectric Point: 7.9859

>T205604 WP_216282326.1 NZ_CP076386:3982362-3982676 [Dickeya dadantii]
MQFTVYGNTGKSAVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQIKAAIDFLIDGI

Download         Length: 315 bp

>T205604 NZ_CP101770:355289-355636 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9057.08 Da        Isoelectric Point: 6.2206

>AT205604 WP_216282325.1 NZ_CP076386:3982123-3982359 [Dickeya dadantii]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLTAALDTELRYHEAKKWQEENREAIDALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT205604 NZ_CP101770:355636-355935 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References