Detailed information of TA system TA205601

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 2786271..2786798
• Replicon: chromosome
• Accession: NZ_CP076386
• Organism: Dickeya dadantii strain S3-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KNV89_RS12330
• Protein ID: WP_216281280.1
• Coordinates: 2786523..2786798 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4V6ESH4
• Locus tag: KNV89_RS12325
• Protein ID: WP_039345626.1
• Coordinates: 2786271..2786519 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KNV89_RS12290 (KNV89_12290)	2781773..2782237	+	465	WP_216281259.1	hypothetical protein	-
KNV89_RS12295 (KNV89_12295)	2782475..2782999	+	525	WP_216281261.1	hypothetical protein	-
KNV89_RS12300 (KNV89_12300)	2783397..2783891	+	495	WP_216281263.1	hypothetical protein	-
KNV89_RS12305 (KNV89_12305)	2783969..2784442	+	474	WP_216281265.1	DNA repair protein RadC	-
KNV89_RS12310 (KNV89_12310)	2784482..2784817	+	336	WP_216281267.1	type IV toxin-antitoxin system YeeU family antitoxin	-
KNV89_RS12315 (KNV89_12315)	2784887..2785207	+	321	WP_216281276.1	TA system toxin CbtA family protein	-
KNV89_RS12320 (KNV89_12320)	2785325..2786158	+	834	WP_216281278.1	DUF4942 domain-containing protein	-
KNV89_RS12325 (KNV89_12325)	2786271..2786519	+	249	WP_039345626.1	ribbon-helix-helix domain-containing protein	Antitoxin
KNV89_RS12330 (KNV89_12330)	2786523..2786798	+	276	WP_216281280.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KNV89_RS12335 (KNV89_12335)	2786846..2787358	+	513	WP_216281282.1	AAA family ATPase	-
KNV89_RS12340 (KNV89_12340)	2787876..2789132	+	1257	WP_216281284.1	tyrosine-type recombinase/integrase	-
KNV89_RS12345 (KNV89_12345)	2789178..2790122	+	945	WP_216281286.1	hypothetical protein	-
KNV89_RS22245	2790231..2790446	-	216	WP_245000992.1	helix-turn-helix transcriptional regulator	-
KNV89_RS12350 (KNV89_12350)	2790542..2790808	+	267	WP_015848023.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2784887..2808377	23490

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 11000.20 Da
• Isoelectric Point: 5.5034

>T205601 WP_216281280.1 NZ_CP076386:2786523-2786798 [Dickeya dadantii]
MEIRWTQKAQDDLERIYGFASQYSRHHADEVLDRLIIGTTGIADHPRIGASQTRYEPREVRKILFDDYEVHYEIQHDTIY
IVDLWHTREDR

Nucleotide

• Length: 276 bp

>T205601 NZ_CP101768:c8087-7773 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9021.41 Da
• Isoelectric Point: 8.7560

>AT205601 WP_039345626.1 NZ_CP076386:2786271-2786519 [Dickeya dadantii]
MGQPAKQTISAQIPAELAAAVESLAIELDRSKSWVIKEALTAMIEERERRHQRILKGLADVDAGRVVSHADVIDFANKLK
KS

Nucleotide

• Length: 249 bp

>AT205601 NZ_CP101768:c8353-8075 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A4V6ESH4